Browsing by Subject "College of Veterinary Medicine"
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Item AHC Vision and Planning: College of Veterinary Medicine Executive Summary(University of Minnesota, 2000-04-07) University of Minnesota. College of Veterinary MedicineItem Building a Bridge Between Distant Agencies With Leadership Skills(2013) University of Minnesota. Center for Animal Health and Food SafetyItem Community-Led Mapping Breaks Cycle of Sickness in Thailand(2012) University of Minnesota. Center for Animal Health and Food SafetyItem Facilities Development Plan(University of Minnesota, 2002-01) University of Minnesota. Academic Health Center College of Veterinary Medicine Facilities Development Planning TeamVeterinary medical facilities have been situated on the University of Minnesota’s St. Paul Campus for at least 110 years. Early documentation, a photo dated 1891, shows a two story wood framed “Veterinary Hospital” located on the present site of the current College of Veterinary Medicine (CVM). In 1901, a brick “Veterinary Building” was constructed replacing the wood framed hospital. This 1901 structure, now titled “Veterinary Anatomy”, still stands - a testament to Veterinary Medicine’s long-standing association with the University’s St. Paul Campus. From this modest beginning, CVM facilities have grown to nearly 600,000 gross square feet. As the college’s programs continue to expand, the need for additional facilities continues to grow. In fact, the Minnesota Facilities Model (MFM) reveals that during the next 5 years, the College will require an additional 40,500 square feet of assignable space to accommodate planned programmatic growth.Item Food Safety from Farm to Table - The Minnesota Model(2013) University of Minnesota. Center for Animal Health and Food SafetyItem FY07 Strategic Investments and Central Allocations: College of Veterinary Medicine(University of Minnesota, 2006) University of Minnesota. Office of the Senior Vice President for Health SciencesItem Gene expression differences between hemangiosarcoma cells in monolayer and non-adherent sphere culture(2011-04-13) Sahli, NathanaelThe cancer stem cell (CSC) theory argues that tumors have a subset of cells that initiate, maintain, and expand cancer in an affected patient. Experimental support for this theory comes from studies that identified sub-populations of cells in a tumor that have the capacity to evade common cancer treatments such as chemotherapy and radiation. Additionally, these same cells exclusively retain the capacity to initiate new disease in xenograft studies. The study of these evasive cells was initially challenging as they differentiate in standard serum-containing culture medium where they grow as a monolayer. In the past decade, methods for culturing stem cells using a serum-free medium has allowed CSCs to be maintained, where they form non-adherent multicellular spheres. Here, we cultured canine hemangiosarcoma (HSA) in both a multicellular sphere and standard monolayer system to compare gene expression using real time qRT-PCR. In our system, the monolayer cultures are a useful surrogate for differentiated tumor cells (the bulk of the tumor), while the serum-free sphere-derived cells are a surrogate for in vivo CSC. Here, we investigate differences in gene expression between these two cultures systems. The genes chosen for study have been shown to be up-regulated in CSCs from various other cancers, or normal stem cells, with minimal expression in differentiated cells. We found gene expression differences between cultures conditions which will allow it to be utilized in the study of hemangiosarcoma as well as possibly other cancers with a CSC.Item In situ analysis of perforin expression in SIV-specific CD8 T cells in tissues from rhesus macaques vaccinated with live-attenuated SIVΔnef and challenged with SIVmac251(2011-04-13) Wagstaff, ReeceHuman immunodeficiency virus (HIV) was identified as the cause of acquired immunodeficiency syndrome (AIDS) in the 1980s, and since then it has proliferated into one of the most vexing pandemics of its time, if not all of human history. As of today, there is still no known cure for HIV, although numerous strategies are currently being pursued to confer immunity. Vaccines represent one of those strategies, and are a plausible method for bestowing resistance to HIV and other lentiviruses. Currently, research exists to show that attenuated vaccines created from simian immunodeficiency virus (SIV), an HIV analogue present in simians such as the Rhesus Macaque, provide suitable resistance for that disease in the simian model. Being that the SIV genome is sufficiently similar to the HIV genome, there is a good probability that an attenuated vaccine created from HIV could produce comparable immunity in humans, however, the mechanism by which SIV vaccines confer resistance is still not well understood and needs to be studied further if attenuated HIV vaccines are ever to be presented in human clinical trials. My hypothesis is that an early, robust, SIV-specific CD8 T cell response in lymph nodes and in the site of infection is responsible for the protection induced from live-attenuated SIV vaccines. To test this hypothesis I quantified perforin assays in lymphatic tissues of immunized macaques that have been challenged with pathogenic SIV. The assays were created by immunohistochemistry staining techniques, including in-situ tetramer staining, and evaluated via scanning confocal microscopy.Item International Cooperation Cracks a Mysterious Epidemic in Uganda(2013) University of Minnesota. Center for Animal Health and Food SafetyItem Interview with Alvin F. Weber(University of Minnesota, 2011-10-06) Tobbell, Dominique A.; Weber, Alvin F.Alvin F. Weber begins by discussing the influence of his rural upbringing on his decision to pursue veterinary medicine through college, at the University of Wisconsin, veterinary school, at the University of Iowa, and graduate studies, again at the University of Wisconsin. He discusses his close brush with military service and his move to the University of Minnesota in 1949. He comments on the impact of the electron microscope and his work on the International Nomenclature Committee. He then recounts his international research during sabbaticals working on cattle leukemia. He discusses his relationships with other faculty members like William Boyd, Bill Thorp, and Sid Ewing. He talks about the 1985 affiliation of the College with the AHC and about running the diagnostics facility at the University of Minnesota. He describes building, both structurally and programmatically, the Veterinary College, funding struggles, increasing numbers of female students over the years, technological and medical advances, and the development of small animal medicine. He also recounts his chromosomal research in cattle.Item Interview with Carl A. Osborne(University of Minnesota, 2011-10-17) Tobbell, Dominique A.; Osborne, Carl A.Dr. Carl Osborne begins with his upbringing, educational background, and childhood relationships with animals. He earned his DVM at Purdue University and took a tenure-track position at the University of Minnesota while he pursued his PhD with a research focus in the urinary tract. He discusses his early years in the Department of Veterinary Medicine, including W. T. S. Thorp’s tenure as dean. He also recounts the relationship of the department to the state legislature in working with large animals and the political influence of the rural population of the state. He describes the potential for retrenchment of the Vet School that occurred in 1988. In reflecting on his time as a researcher, clinician, and teacher, Dr. Osborne shares his philosophies on life, teaching, and veterinary medicine. He describes the leadership changes within and the politics of the school, exploring some of the conflicts that arose over the course of his career. In discussing changing leadership, Dr. Osborne also comments on his own leadership roles. He then describes the internal and external relationships of the vet school, in aligning itself with the Academic Health Center and establishing reciprocity with the University of Wisconsin. Dr. Osborne returns to discussions of leadership within the school in describing the tenures of deans Sidney Ewing, David Thawley, and Bob Dunlop. In returning to his role within the department as clinician, researcher, and teacher, Dr. Osborne again shares his philosophy of veterinary medicine.Item Interview with Carl R. Jessen(University of Minnesota, 2011-08-12) Tobbell, Dominique A.; Jessen, Carl R.Carl Jessen begins his interview by discussing his upbringing, his interest in veterinary medicine, and his education. He follows this with his entrance into private practice and then his return to school for a Ph.D. in qualitative genetics and radiology. He then reflects on changes in the department over the period when he first entered the DVM program, to his reentrance for a Ph.D. and subsequent hiring as a faculty member, and then makes a modern comparison. Within his reflection on the school, Jessen discusses budgetary problems in the teaching hospital, the push for the faculty to get a constitution and faculty council, the relationship between the School and the legislature in terms of funding, and the growth of the profession. Within his own career, Jessen shares his philosophy on the balance of research, teaching, and clinical work. In terms of the land grant mission of the University, he also considers relationships between the Vet School and out-of-state students and between the School and the community. Reviewing the history of the school under Dean Sidney Ewing, Jessen relates the effects of changes in the structure of the school and the school’s loss of accreditation in the mid 1970s. Pursuant with these changes in the mid 1970s, he also relates changes in the profession and the school that led to an increase in the number of female students. He then speaks to relations with the University of Wisconsin, his duties as associate dean and director of the hospital, Robert Dunlop’s tenure as dean, budget problems and the hospital business model, the School’s emphasis on teaching over research, the integration of the Vet School into the AHC, the deanships of Jeff Kausner and David Thawley, and the connection between the Vet School and the legislature through animal industries. He ends the interview by again emphasizing the teaching mission of the School.Item Interview with Neal A. Vanselow(University of Minnesota, 2013-07-10) Tobbell, Dominique A.; Vanselow, Neal A.Dr. Neal Vanselow begins his interview by reflecting on his education and training at the University of Michigan and his internship at Minneapolis General Hospital (now Hennepin County Medical Center). He then discusses his tenure as dean at the University of Arizona College of Medicine and his move to the University of Nebraska Medical Center in Omaha. He relates the reasons for his move to the University of Minnesota Academic Health Center (AHC). Concerning the University’s AHC, Dr. Vanselow describes all of the following: the culture of the AHC particularly town/gown relationships; the relationship between the AHC and the rest of the University; the relationship between the AHC and Central Administration; relations among units in the health sciences; the incorporation of the College of Veterinary Medicine into the AHC; and Ken Keller’s Commitment to Focus and the threatened closure of the Dental School and the College of Veterinary Medicine. Reflecting on larger trends in healthcare and health education, he discusses: efforts to admit more minority students; issues regarding the rising costs of hospital care and the impact on University Hospital; faculty practice; retrenchments; the creation of the Biomedical Ethics Center; and the issues surrounding the University’s production and sale of Antilymphocyte Globulin (ALG). Dr. Vanselow also describes the tenures of the presidents of the University and the regents with which he worked; his work with the Legislature; the differences between a private and public academic health center; and his time on the board of the Association of Academic Health Centers. He concludes his interview with a reflection on his experiences as part of the Institute of Medicine’s Committee on the Future of Primary Care and the Continuing Evaluation Panel of the American International Health Alliance.Item Interview with Robert K. Anderson(University of Minnesota, 2012-05-31) Tobbell, Dominique A.; Anderson, Robert K.In the first interview, Robert K. Anderson begins by describing his background, including his childhood, education, his service in the military, his early career, and his reasons for pursuing degrees in veterinary medicine and public health. He discusses his experiences on the faculty of the University of Colorado Medical School, in private practice, as a faculty member of the University of Minnesota, and as an epidemiology teacher for the Pan American Health Organization. He goes on to describe the following: One Health and comparative health; collaboration among the different health science units at the University; his research on brucellosis; his work with rabies for Veterinary Public Health in Denver; the College of Veterinary Medicine’s (CVM) accreditation; the relationship among Veterinary Medicine, UMN central administration, and the Legislature; comparative funding for the CVM and the School of Public Health; and the CVM’s relationship with industry and the USDA. Concerning education within the CVM, Anderson discusses his teaching, the growth of veterinary manpower, women in veterinary medicine, and the recruiting of minority students. He then explores the merging of the CVM with the health sciences and his research on radiation and bovine leukemia. Later in his career, Anderson studied psychology, which led to his interest in human-animal bonds and animal behavior. He considers this work as foundational to creating the Gentle Leader® , reforming his beliefs about dog training, and prompting the establishment of the American College of Veterinary Behaviors, the Delta Society, and the Center to Study Human Animal Relationships and Environments. Among the figures he discusses in his interview, Anderson is particularly attentive to the roles of William T.S. Thorp, Joseph Massey, and Sidney Ewing in his career. In the second interview, Robert K. Anderson and David Garloff focus most of their discussion on the Center to Study Human-Animal Bonds and Environments (CENSHARE), including its establishment, research, interactions with other university centers, and programs doing work on human-animal bonds, funding, educational programs and courses, its products and programs, many of the people and volunteers involved over the years, and other topics. They also discuss Temple Grandin, the Gentle Leader®, NIH funding of veterinary medicine studies, the Delta Society, Helping Paws, Anderson’s work as Chief of Veterinary Public Health Services for Denver, and disease transmission between animals and humans.Item Interview with Victor Perman(University of Minnesota, 2011-10-27) Tobbell, Dominique A.; Perman, VictorDr. Victor Perman begins his interview with a reflection on where he was born and raised, his time in the Navy, and his interest in pursuing veterinary medicine. He then describes his education at the University of Minnesota’s College of Veterinary Medicine, his work in the clinical pathology laboratories, his pursuit of a Ph.D., and his research at Brookhaven National Library and at the University of Minnesota. Dr. Perman then describes W.T.S. Thorp’s tenure as dean; funding for the College and accreditation issues; relations between the College and Minnesota farm groups; shortages of veterinarians; veterinary medicine and public health; the creation of the new University Veterinary Hospital; and emerging medical technologies in the 1960s and 1970s. In part two of his interview, Dr. Perman begins by discussing Sidney Ewing’s tenure as dean and the reorganization of the College. He then reflects on efforts to align the College with the other health sciences, Robert Dunlop’s tenure as dean and his reorganization of the College, collaborations within and outside the College, and evaluation procedures within the College.Item Lead from Spent Ammunition: A Source of Poisoning in Bald Eagles(2009-10-07) Cruz, Luis; Redig, Patrick T.; Smith, Donald R.A 12-year (1996-2008) retrospective study of lead poisoning in bald eagles (Haliaeetus leucocephalus) was conducted to test the hypothesis that spent lead from ammunition, present in the carcasses and gutpiles of white-tailed deer, represents an important source of lead exposure. Sample size consisted of n=300 lead poisoning cases from 1,150 eagles admitted.Item The location, abundance, and proliferation status of SIV-specific CD8 cells in rhesus macaques vaccinated with live attenuated SIVΔnef and challenged with the pathogenic SIVmac251(2011-04-13) Nguyen, Tammy TranOver 30 million people are infected with HIV/AIDS today. There is an urgent need to develop an effective vaccine. Simian immunodeficiency viruses (SIVs) in rhesus macaques serve as a valuable animal model of HIV infection. Live attenuated SIVs provide protection in SIV infected rhesus macaques challenged with highly pathogenic SIV. The goal of this experiment is to identify correlations of protection that is provided by SIVΔnef vaccination. Here I determined the abundance, location and activation/proliferation status of SIV-specific CD8 T-cells in lymph nodes and spleen from SIVΔnef vaccinated rhesus macaques before and after challenge with the pathogenic SIVmac251. Confocal images were obtained from tissues stained with MHC-tetramers that stain SIVspecific CD8 T cells and Ki67 antibodies that stain proliferating cells and activated T cells. We found similar numbers of SIV-specific CD8 T cells, and similar percentages of SIV-specific CD8 T cells before and after challenge. These results demonstrate that 1) SIV-specific CD8 T cells were present in lymphoid tissues at the time of challenge, and 2) no expansion of SIV-specific CD8 T cells in lymph nodes and spleen was required for protection. This study yields insights into CD8 T cell responses that are likely needed to be induced by a successful HIV vaccine.Item Predesign for the University of Minnesota Equine Center(University of Minnesota, 2004-05) University of Minnesota. Academic Health Center Office of FacilitiesItem Provost’s Charge to Task Force on College Design: Small Colleges(University of Minnesota: Office of the Provost, 2005-09-15) Sullivan, E. ThomasLetter and supporting documents comprising the charge to the Provost’s Academic Task Force on College Design: Small CollegesItem Role of CD38/cyclic-ADP-ribose in Human Asthma(2009-04-08) Smelter, Dan F.CD38 is a cellular protein found throughout the mammalian body. It is involved in calcium signaling and innate immunity. Its expression is augmented by the presence of multiple contractile agonists that occur in the development of asthma, and it is implied that CD38 expression is involved in the pathogenesis of asthma. However, CD38's role in human asthma has not been described. In my studies, I wanted to determine whether CD38 expression is involved in human asthma. To test this, I studied the effects of TNF-alpha-induced augmented CD38 expression in airway smooth muscle cells obtained from asthmatics compared to non-asthmatics. Also, I tested the intracellular calcium response to contractile agonists in cells from asthmatics and non-asthmatics following exposure to TNF-alpha.