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Abnormal Recovery from Acute Stress in Huntingtons Disease Mice

Zacharoff, Lori
Hamid, Arif
Engeland, William C
Dubinsky, Janet M
2018-03-12
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https://doi.org/10.13020/D6C105
 https://hdl.handle.net/11299/194497
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20070327
20110328

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2018-03-12

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Title

Abnormal Recovery from Acute Stress in Huntingtons Disease Mice

Published Date

2018-03-12

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Dubinsky, Janet M
dubin001@umn.edu

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Experimental Data

Abstract

Comparisons of hypothalamic dysfunction between Huntington’s Disease (HD) patients and rodent models of HD have not always yielded similar results. Cortisol levels in HD patients have been contradictory, with reports ranging from hypo- to hypercorticoidism of morning measurements. Initial reports of major elevations in circulating corticosterone levels in the R6/2 mouse model of HD have only been followed up in one other closely related model, the R6/1 mouse, and the results were not perfectly congruent. To determine if abnormal stress hormones were a characteristic of disease, we examined diurnal and stress-induced corticosterone levels in multiple HD mouse models.

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Deposited here are Excel files containing the data that compose several figures used in the referenced paper.

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Attribution-NonCommercial-NoDerivs 3.0 United States
 http://creativecommons.org/licenses/by-nc-nd/3.0/us/

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Data Repository for U of M (DRUM)
Janet M Dubinsky

Funding information

This work was funded by CHDI, Inc and the Strom Family Fund to JMD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Zacharoff, Lori; Hamid, Arif; Engeland, William C; Dubinsky, Janet M. (2018). Abnormal Recovery from Acute Stress in Huntingtons Disease Mice. Retrieved from the Data Repository for the University of Minnesota (DRUM), https://doi.org/10.13020/D6C105.

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Table1Data.xlsx
Data contributing to Table 1
(21.61 KB)

Fig1Data.xlsx
Data contributing to Fig. 1
(23.7 KB)

Fig2Data.xlsx
Data contributing to Fig. 2
(19.71 KB)

Fig3Data.xlsx
Data contributing to Fig. 3
(18.46 KB)

Fig4Data.xlsx
Data contributing to Fig. 4
(15.29 KB)

Fig5Data.xlsx
Data contributing to Fig. 5
(9.28 KB)

Fig7Data.xlsx
Data contributing to Fig. 7
(9.45 KB)

Cort paper_3-12-18.docx
manuscript to be submitted
(996.19 KB)

Readme.txt
Description of files
(10.54 KB)

Cort paper_3-12-18.pdf
Manuscript in PDF format
(1.04 MB)

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