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Browsing by Subject "canine"

Now showing 1 - 5 of 5
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    2007 Sled Dog Sports Participant Survey
    (University of Minnesota Tourism Center, 2007) Steele, Dave
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    CT radiomic features for canine primary lung tumors
    (2021-07-20) Wolf-Ringwall, Amber; Rendahl, Aaron; Seelig, Davis; Ober, Chris; Able, Hannah; Wilke, Chris; Lawrence, Jessica; jlawrenc@umn.edu; Lawrence, Jessica; University of Minnesota Veterinary Oncology
    Quantitative analysis of computed tomography (CT) radiomic features is an indirect measure of tumor heterogeneity, which has been associated with prognosis in human lung carcinoma. Canine lung tumors share similar features to human lung tumors and may serve as a model in which to investigate the utility of radiomic features in differentiating tumor type and prognostication. The purpose of this study was to correlate first-order radiomic features from canine primary lung tumors to histopathologic characteristics and outcome. Sixty-seven tumors from 65 dogs were evaluated in this study.
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    Data from "Diverse Bacterial Communities Exist on Canine Skin and are Impacted by Cohabitation and Time"
    (2016-11-17) Johnson, Timothy; Torres, Sheila; Danzeisen, Jessica; Clayton, Jonathan; Ward, Tonya; Knights, Dan; Huang, Hu; joh04207@umn.edu; Johnson, Timothy
    This related study sampled 40 dogs from 20 households over the course of three seasons. Three skin sites were examined. The goal of the study was to determine if a core skin microbiome exists in dogs across time and body site, and if cohabitation impacts sharing of the skin microbiome. This dataset is a part of the Torres_Johnson Canine Microbiome Study.
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    Myeloid derived suppressor cells in dogs with cancer: phenotype, function and clinical implications
    (2014-06) Goulart, Michelle Rodrigues
    Myeloid-derived suppressor cells comprise phenotypically heterogeneous population of myeloid cells at different stages of differentiation endowed with potent immunosuppressive activity. Abnormal accumulation of MDSC in tumor models and cancer patients produce profound immune suppression, severely impairing T cell antitumor immunity, contributing to angiogenesis, cell invasion and metastasis, and constitute a major hurdle in achieving successful immunebased therapies. Understanding the mechanism that drives MDSC expansion and enhances function in humans and dogs is crucial for the development of efficacious immunotherapy. Studies in dogs with several tumor types, including sarcoma, carcinomas, mast cell tumors and gliomas confirmed MDSC expansion in the peripheral blood of dog cancer patients. MDSC have been identified in dogs using the combination of three-marker phenotype CD11b+CD14-MHCII-cells for granulocytic and CD11b+CD14+MHCII-cells for monocytic subsets. Granulocytic MDSC accumulated in the peripheral blood of dogs with advanced sarcoma, carcinomas and mast cell tumors, co-purified with peripheral blood mononuclear cell (PBMC) fraction and expressed polymorphic mononuclear morphology. This subset of cells showed the ability to efficiently inhibit T cell proliferation and IFN-γ secretion of autologous T cells, as well as allogenic T cells from healthy dogs, and expressed ARG1, iNOS2, TGF-β and IL-10. Monocytic MDSC also demonstrated potent ability to suppress T cell proliferation and preferentially accumulated in the peripheral blood of dogs with glioma. Elevated levels of arginase activity found in the serum of dogs with glioma could potentially be due to the presence of elevated numbers of MDSC. Evaluation of the anti-mouse Gr1 antibody for MDSC staining and identification revealed that does not cross react and therefore is not suitable for canine cells.
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    Whole Genome Imputation Panel of 624 Dogs
    (2023-03-09) Friedenberg, Steven; Clark, Leigh Anne; Murphy, Sarah; Greif, Elizabeth; Evans, Jacquelyn; Tsai, Kate; fried255@umn.edu; Friedenberg, Steven
    This dataset contains a compressed variant call file (VCF) and index file of phased, bi-allelic, single nucleotide variants (SNVs) from 624 dogs of various breeds that were used as a reference panel for imputation of low-pass whole-genome sequencing from 83 Great Danes. Also included is an Excel file containing breed information for each of the 624 dogs. The file contains data for all 38 canine autosomes and the X chromosome.