Browsing by Subject "College of Pharmacy"

Now showing 1 - 20 of 29
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    AHC Strategic Planning Process: College of Pharmacy Faculty Response
    (University of Minnesota, 2000-04-24) University of Minnesota. College of Pharmacy
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    Characterization of Death Receptor 5 Targeting Nanoring Cancer Drugs
    (2012-04-18) Palmatier, Katelyn
    To maximize the effectiveness and minimize the adverse effects of chemotherapeutic agents, it is strategic to create drugs that specifically target cancer cells via ligand-receptor interactions. Several variations of a drug containing a ligand that binds to Death Receptor 5 were created and in vitro properties were characterized.
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    COMPUTATIONAL AND EXPERIMENTAL SCREENING STRATEGIES TOWARD NOVEL ANTHRAX TOXIN LETHAL FACTOR INHIBITORS
    (2010-11-29) Patel, Ajay
    Here, 9 lead compounds, with at least micromolar-level inhibition of LF as determined by experimental High Throughput Screening (HTS), were tested against virtual databases using programs such as Volsurf (Tripos SYBYL) and QikProp (Schrodinger Maestro) to predict various pharmacokinetic properties such as Blood Brain Barrier (BBB) permeability, percent Human Intestinal Absorption (%HIA) and HERG K+ channel blockage (HERG).
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    Cost Construction Study: Nursing and Pharmacy
    (University of Minnesota, 1983-03) University of Minnesota. Health Sciences Center
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    Development of an Analytical Assay for the Determination of Vinpocetine’s Primary Metabolite, Apovincaminic Acid, in Human Plasma
    (2012-04-18) Gao, Robert; Paz, Matt
    Vinpocetine (VP) is a derivative obtained from (+) vincamine, and is commonly extracted from periwinkle. It has been shown to alleviate risks associated with stroke by enhancing cerebral blood flow. VP is also useful for the treatment of epilepsy and for the prevention of dementia. Current research is examining whether VP’s therapeutic effect is due to its active metabolite, AVA.
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    Development of APOBEC3 Cytosine Deaminase Inhibitors
    (2011-09-27) Grover, Torie; Perkins, Angela; Li, Ming; Harris, Reuben; Harki, Daniel
    The APOBEC3 (A3) family of proteins degrade non-native or ‘foreign’ DNA in cells. We have hypothesized that blocking the enzymatic activity of A3 proteins could enhance the efficiency of foreign DNA introduction (transfection) into cells that are otherwise refractory to the process. APOBEC3 proteins degrade ‘foreign’ DNA by converting cytosines into uracils, which then triggers the cell to degrade the DNA due to the presence of a non-native DNA base (uracil). To identify small molecules that could inhibit A3 proteins, High Throughput Screening (HTS) was performed at the University of Minnesota and the Sanford-Burnham Medical Research Institute and over 350,000 compounds were tested for inhibition of A3A and A3G proteins. Follow-up studies by the Harris laboratory (University of Minnesota) have identifed hundreds of potential candidate molecules that can inhibit A3 activity in vitro. Three lead molecules from this study include MN152, MN184 and MN132. The Harki laboratory (University of Minnesota) is collaborating with the Harris laboratory to conduct detailed medicinal chemistry campaigns to optimize lead molecules for strong potency and minimal toxicity. Preliminary results from our synthesis studies of these chemotypes are presented here.
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    Experiences and Perceptions of Telehealth Amongst Rural Dwelling Senior Citizens
    (2025-04-24) Curry, Joshua
    Rural areas in the United States have a rising population of senior citizens with medical needs. Limited physician availability is especially noticeable in rural medical deserts. This study sought to discover the experiences and perceptions of online-based healthcare delivery, telehealth, among the rural-dwelling senior citizens of Pope County, MN. Using in-person interviews, participants shared their personal views on telehealth and how it impacts their rural residence. Themes of perceived facilitators, barriers, and benefits of telehealth were analyzed, and their social support and experience with technological devices were understood. The findings of this study highlight critical barriers in senior citizens' perceptions of telehealth and their recommendations for improving operability for aging adults in rural areas.
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    Future Planning for the Health Sciences College of Pharmacy: Part II. Staff and Space Projections
    (University of Minnesota, 1967-11-01) University of Minnesota. College of Pharmacy
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    FY07 Strategic Investments and Central Allocations: College of Pharmacy
    (University of Minnesota, 2006) University of Minnesota. Office of the Senior Vice President for Health Sciences
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    Interview with Albert I. Wertheimer
    (University of Minnesota, 2019-10-22) Ruhrold, Lauren N.; Wertheimer, Albert I.
    Dr. Wertheimer begins his interview by describing his early life and educational background. He reflects on his undergraduate education at the University of Buffalo and on his choice to pursue a career in pharmacy. He discusses his interest in marketing and his pursuit of an M.B.A. at Buffalo. Dr. Wertheimer then discusses his decision to pursue a Ph.D. in pharmacy at Purdue University. He describes his time working as a hospital pharmacist in Lafayette, Indiana and as a community pharmacist in Buffalo, New York. Dr. Wertheimer discusses his path post-graduation, reflecting on his time as assistant professor at SUNY Buffalo and on his work with the Social Security Administration. He then describes the circumstances surrounding his move to the University of Minnesota and his attraction to the Twin Cities. Dr. Wertheimer reflects on his early years in the College of Pharmacy, the mentorship of Dean Lawrence Weaver, the significance of the Academic Health Center (AHC), and the emergence of the Pharm.D. degree. He then discusses the history of the Department of Social and Administrative Pharmacy describing its origin and development, ensuing turf battles, as well as notable faculty and alumni. He also discusses the founding and development of the Kellogg program. Dr. Wertheimer reflects on the growth of clinical pharmacy, shifts in promotion and tenure procedures, and changes to the pharmacy curriculum. He then discusses his experience as a community pharmacy owner, as well as changes in the interaction between pharmacists and patients. He also reflects on his roles as Vice President for First Health Services Corporation and as Director of Outcomes Research and Management for Merck and Company. Dr. Wertheimer then discusses changes in the leadership of the UMN College of Pharmacy and his activities as director of graduate studies. He describes his departure from UMN and reflects on how the College of Pharmacy compares to other educational institutions. He concludes by commenting on more recent developments in the college and by reflecting on his relationship with Dean Lawrence Weaver.
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    Interview with Donald L. Uden
    (University of Minnesota, 2019-10-14) Ruhrold, Lauren N.; Uden, Donald L.
    Dr. Uden begins his interview by discussing his childhood and high school experience in Coon Rapids, Minnesota. He then reflects on his coming to the University of Minnesota as an undergraduate, his early experiences with pharmacy practice, memorable classes, and his interaction with the medical school. He then describes the development of the Pharm.D. program and changes in the popular image of a pharmacist. He then discusses the significant relationships he formed with Dr. Lawrence Weaver and with peers through the professional fraternity Kappa Psi. He then reflects on his post-graduate work at the St. Paul-Ramsey Medical Center, his increasing involvement with pharmacokinetics, and his growing interest in clinical research. Dr. Uden then describes his time at Minneapolis Children’s Medical Center, his role there as Director of Pharmacy, and his work in pediatric and emergency care. Dr. Uden then discusses his return to the University of Minnesota as a faculty member and reflects on his experience with tenure policies and procedures. He then discusses the growth of clinical pharmacy and the pharmaceutical care movement. He then describes the Pharmacy Rural Education Program (PREP), as well as the development of the Rural Health School and his role as interim director. He then reflects on the deanship of Gilbert Banker, the state of the University of Minnesota College of Pharmacy in the 1990s, and the dynamic between Rho Chi and Lo Chi. Dr. Uden concludes by discussing the Doctor of Pharmacy Program for Practicing Pharmacists (DP4) and reflecting on his experience as Associate Dean of Students.
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    Interview with Frank Cerra
    (University of Minnesota, 2014-07-31) Cerra, Frank B.; Tobbell, Dominique
    Dr. Frank Cerra begins part one of his interview by describing his undergraduate education at SUNY Binghamton, his medical education at Northwestern University Medical School, and his residency at SUNY Buffalo. He then describes his recruitment to the University of Minnesota, his early goals, and his growing administrative roles. He describes the leadership implications of investigations into Antilymphocyte Globulin (ALG) on the Medical School and the merging of University Hospital with Fairview Health Services. He then discusses the following topics: his interest in surgery; the culture of the University of Minnesota’s Department of Surgery; his work with the pharmaceutical industry and the College of Pharmacy; his work developing a critical care program at the University; and his relationships with the hospital directors, hospital nursing, and the School of Nursing. In part of two his interview, Dr. Cerra intersperses reflections on finances and relations among different levels of administration in the University, the AHC, and University Hospital. He also discusses the following topics: his relationship with Neal Gault; strategic and long-range planning; the goals of the AHC; the formation of University of Minnesota Physicians; the establishment of the Biomedical Ethics Center (later the Center for Bioethics) and the Masonic Cancer Center; the investigations into ALG and Dr. John Najarian; the establishment of the Center for Drug Design; William Brody as Provost of the AHC and issues surrounding faculty tenure; and the establishment of the Institute for Health Informatics. In part three of his interview, Dr. Cerra expands on the decision to merge University Hospital with Fairview Health Services, particularly focusing on logistics, culture, and reception. He also discusses failed attempts to create a unified children’s hospital in the Twin Cities. He then reflects on the following topics: the major challenges and achievements of his tenure as senior vice president; the merging of the positions of Senior Vice President of Health Sciences and Dean of the Medical School; the creation of the Clinical and Translational Science Institute and the Biomedical Discovery District; and the medical device industry in Minnesota. He concludes by describing the University of Minnesota and Mayo Clinic partnership in research.
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    Interview with John Kralewski
    (University of Minnesota, 2011-02-14) Tobbell, Dominique A.; Kralewski, John
    John Kralewski begins by describing his background, including his education, his service in the Air Force, his early career, and why he went into the health sciences. He discusses his experiences as student in pharmacy and then in hospital administration at the UMN. He discusses the Program in Hospital Administration at UMN; hospital administration as a field in the 1960s and 1970s; the School of Public Health; funding; his research; efforts to introduce mandatory generic prescribing in the 1960s; pharmacy as a profession; nursing; the divisions within the School of Public Health in the 1960s; leadership in the health sciences at the UMN; University Hospitals; other hospitals in the Twin Cities; and the University of Minnesota’s decision to sell University Hospitals to Fairview. He talks about Gaylord Anderson, James Hamilton, Cherie Perlmutter, Stephen Joseph, Lyle French, Frank Cerra, and others in leadership and administrative position in the Health Sciences. In his second interview, John Kralewski discusses his experiences as assistant vice president for Health Sciences. He talks about the Center for Health Services Research; health services research at Minnesota and around the country; working with the Minnesota state legislature; rural health care; the Health Information Foundation (at the University of Chicago); moving the Center for Health Services Research out of the vice president’s office and into the School of Public Health; the Hospital Administration program; graduate programs in Public Health; relations between the Academic Health Center administration and the state legislature; the relationship between the health sciences units, and health sciences education and funding. He discusses Lyle French, Neal Vanselow, and Robert Kane.
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    Interview with Lawrence Weaver
    (University of Minnesota, 1999-02-12) Weaver, Lawrence Clayton; Pflaum, Ann M.
    Ann Pflaum interviews Dr. Lawrence Weaver of the College of Pharmacy.
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    Interview with Lawrence Weaver, February 12, 1999
    (University of Minnesota, 1999-02-12) Weaver, Lawrence C.; Pflaum, Ann M.
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    Interview with Lowell Anderson
    (University of Minnesota, 2012-08-01) Tobbell, Dominique A.; Anderson, Lowell
    Lowell Anderson begins his interview with a reflection on his early life and education, highlighting his experience earning a bachelor’s degree in pharmacy from the University of Minnesota. He describes the profession’s receptiveness to female pharmacists, his recollections of the Kefauver Hearings regarding prescription drug pricing in the early 1960s, and the impact of managed care on pharmacy. He goes on to discuss his professional goals; his time at Walgreen’s as a pharmacy student; his early career, including time at Northwestern Hospital and the State Department of Administration; and his experience of ownership of pharmacies in Falcon Heights (1966) and White Bear Lake. Within this discussion, he reflects on how relationships between health care professionals and pharmacists change in different venues, the differences between a chain pharmacy and a privately owned pharmacy, building community relationships, generic substitution, the patient package insert, patient expectations regarding drug advice from doctors and pharmacists, the function of Pharmacy Benefit Managers. The conversation then transitions to the Academic Health Center and Mr. Anderson’s contributions to the College of Pharmacy. The following topics are discussed: the introduction of clinical pharmacy in the College; relations between basic scientists and professional pharmacists in the College; relations among schools and colleges in the AHC; the potential creation of the Pharmacy Technician Program; the threatened shortage of pharmacists; the creation of the Department of Social and Administrative Pharmacy; the development of pharmaceutical care practice; and the Center for Leading Healthcare Change. He concludes his interview with current policy issues in which pharmacists should adopt a larger role.
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    Interview with Marilyn K. Speedie
    (University of Minnesota, 2019-07-31) Ruhrold, Lauren N.; Speedie, Marilyn K.
    Dr. Speedie begins part one of her interview by describing her early life and educational background. She reflects on her undergraduate education at Purdue University, discussing her early experiences working in community pharmacies and her exposure to laboratory research. She briefly discusses her time in graduate school and reflects on her return to Oregon following graduation. She discusses her move to Baltimore, as well as her becoming assistant professor and department head at the University of Maryland. Dr. Speedie then reflects on being recruited to the University of Minnesota. She discusses the appeal of an administrative position, as well as her ongoing interest in teaching and research. She reflects on the chaotic state of the University of Minnesota College of Pharmacy upon her arrival, the mentorship she received, and the openness of the pharmacy profession to women. Dr. Speedie then discusses some of the College’s more famous research projects, including investigations into epilepsy, HIV, and opioids. She then details the founding of the Rural Health School and the impetus behind the Duluth expansion. She concludes by comparing revisions made to the College of Pharmacy curriculum in 1995 and 2013 and by reflecting on faculty responses to those changes. Dr. Speedie begins part two of her interview by offering some additional comments about curricular design and the contributions of specific people to that project. She then reflects on changes in pharmacy practice in the mid 2000s, describing the significance of medication therapy management (MTM), collaborative practice, and pharmaceutical care. She then discusses the changing status of the Pharm.D. degree. Dr. Speedie then reflects on the founding and vision behind the Doctor of Pharmacy Program for Practicing Pharmacists (DP4). She then describes the relationship between academic and practicing pharmacists and discusses Dr. Lawrence Weaver’s role in bridging these groups. She discusses the significance of the Center for Leading Health Care Change and the Academic Health Center (AHC). She briefly reflects on the difficulties involved with connecting the College of Pharmacy and Fairview Health Services and with securing physical space for the College. Dr. Speedie concludes by commenting on her position as the first female dean and on the future of pharmacy enrollments.
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    Interview with Neal A. Vanselow
    (University of Minnesota, 2013-07-10) Tobbell, Dominique A.; Vanselow, Neal A.
    Dr. Neal Vanselow begins his interview by reflecting on his education and training at the University of Michigan and his internship at Minneapolis General Hospital (now Hennepin County Medical Center). He then discusses his tenure as dean at the University of Arizona College of Medicine and his move to the University of Nebraska Medical Center in Omaha. He relates the reasons for his move to the University of Minnesota Academic Health Center (AHC). Concerning the University’s AHC, Dr. Vanselow describes all of the following: the culture of the AHC particularly town/gown relationships; the relationship between the AHC and the rest of the University; the relationship between the AHC and Central Administration; relations among units in the health sciences; the incorporation of the College of Veterinary Medicine into the AHC; and Ken Keller’s Commitment to Focus and the threatened closure of the Dental School and the College of Veterinary Medicine. Reflecting on larger trends in healthcare and health education, he discusses: efforts to admit more minority students; issues regarding the rising costs of hospital care and the impact on University Hospital; faculty practice; retrenchments; the creation of the Biomedical Ethics Center; and the issues surrounding the University’s production and sale of Antilymphocyte Globulin (ALG). Dr. Vanselow also describes the tenures of the presidents of the University and the regents with which he worked; his work with the Legislature; the differences between a private and public academic health center; and his time on the board of the Association of Academic Health Centers. He concludes his interview with a reflection on his experiences as part of the Institute of Medicine’s Committee on the Future of Primary Care and the Continuing Evaluation Panel of the American International Health Alliance.
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    Interview with Norrie Thomas
    (University of Minnesota, 2013-11-21) Klaffke, Lauren E.; Thomas, Norrie
    Norrie Thomas was born in Detroit, Michigan but grew up in Rochester, Minnesota. She completed two years at a junior college in Rochester and transferred to the University of Minnesota in 1971. She earned her bachelor’s in pharmacy in 1976. She worked as a staff pharmacist at Saint Mary’s Hospital and the Mayo Clinic before returning to the University of Minnesota as a graduate student. She earned her master’s and doctorate in pharmacy administration in 1980 and 1983, respectively. She made important strides in developing the field of pharmacy benefit management (PBM) over the course of her career, co-founding one of the first PBM companies, Clinical Pharmacy Advantage, in 1990. Over the course of her career, Dr. Thomas has held senior management positions at all of the following companies: MedCenters Health Plans, Aetna, McKesson, PCS, Eli Lilly, St. Jude Medical, Schering-Plough, and Magellan Health Services. She also helped establish the Academy of Managed Care Pharmacy. From 2009 to 2010, Dr. Thomas served as an adjunct professor at the University, coordinating Dialogues in Managed Care Pharmacy Leadership, which sought to highlight leadership within the pharmacy profession. She currently serves president and managing director of Manchester Square Group.