Deregulation of microRNA Processing in Idiopathic Pulmonary Fibrosis

Guenther, Kacey
2015
Thumbnail Image

View/Download File

Kacey Guenther magna CBS sp2015.pdf (928.22 KB)

Persistent link to this item

https://hdl.handle.net/11299/174008
Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

Deregulation of microRNA Processing in Idiopathic Pulmonary Fibrosis

Authors

Published Date

2015

Publisher

Type

Thesis or Dissertation

Abstract

Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with an incidence in the United States of 42.7 to 63 per 100,000 and an incidence in Europe of 16.3 to 17.4 per 100,000 (Nalysnyk et al. 2012). Incidence and severity of IPF increases with age, but on average projected survival is just 3-4 years post-diagnosis (Raghu et al. 2014). Until recently, treatment options have been limited and mostly palliative, with little impact on survival. For many years, the only established treatment shown to extend life was lung transplantation. However, lungs are the most difficult organs to transplant, with patients surviving an average of just 4.6 years post-transplantation (NIH 2014). Just recently, two drugs (pirfenidone and nintedanib) have been approved for treatment of IPF. However, even with such treatments the unyielding progression of IPF is only slowed, and a more effective treatment for IPF remains both necessary and illusive (as reviewed in Jenkins and Goodwin 2014).

Keywords

Description

Related to

Replaces

License

Collections

Undergraduate Honors Theses

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Guenther, Kacey. (2015). Deregulation of microRNA Processing in Idiopathic Pulmonary Fibrosis. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/174008.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.