Data and analyses files for "Evidence for Complex Interplay between Quorum Sensing and Antibiotic Resistance in Pseudomonas aeruginosa"
2022-09-26
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2020-01-07
2022-09-26
2022-09-26
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2022-09-26
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Title
Data and analyses files for "Evidence for Complex Interplay between Quorum Sensing and Antibiotic Resistance in Pseudomonas aeruginosa"
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2022-09-26
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Elias, Mikael H
mhelias@umn.edu
mhelias@umn.edu
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Experimental Data
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Experimental Data
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Abstract
This data set contains the experimental data, corresponding analysis files and final and intermediary figure files used in the manuscript titled "Interference in microbial signaling highlights the complex relationship between quorum sensing and antibiotic resistance in Pseudomonas aeruginosa" and is intended to be made publicly available for readers and reviewers. It contains the data files from BioTek HTX/Epoch2 Microplate reader for Pseudomonas aeruginosa growth with lactonases/AHLs in Biolog Phenotype MicroArrays(TM) PM11-PM20 and additional replicate experiments done with Pseudomonas aeruginosa growing in Biolog IF-10A media with antibiotics/antimicrobial compounds and lactonases/AHLs. It also contains qPCR data from Thermo Scientific StepOnePlus(TM) Real Time PCR system for assessment of transcription levels of Pseudomonas aeruginosa folA and folP genes. Additionally, all associated and annotated analysis files generated in Microsoft Excel and GraphPad Prism are included. Analysis data from Caenorhabditis elegans killing assays are also included. All the intermediate and final figures that are used in the manuscript are provided as Microsoft PowerPoint files for easy visualization of the workflow and processing.
Description
All data is arranged according to Figure Numbers used in the manuscript. Each figure is represented by a folder named [Figure Number] and a corresponding PowerPoint file named [Figure Number], that denotes the assembled figure is its intended final form. All sub-folder and file names are self explanatory in context of the figures referencing the data. All experimental data and analysis have been carefully annotated and are self-explanatory.
Referenced by
Interference in microbial signaling highlights the complex relationship between quorum sensing and antibiotic resistance in Pseudomonas aeruginosa. https://doi.org/10.1128/spectrum.01269-22
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This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R35GM133487.
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Suggested citation
Sikdar, Rakesh; Elias, Mikael H. (2022). Data and analyses files for "Evidence for Complex Interplay between Quorum Sensing and Antibiotic Resistance in Pseudomonas aeruginosa". Retrieved from the Data Repository for the University of Minnesota (DRUM), https://doi.org/10.13020/1jgd-h107.
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