Exceptionally Elastic Single-Component Pharmaceutical Crystals
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Exceptionally Elastic Single-Component Pharmaceutical Crystals
Alternative title
Published Date
2019
Publisher
ACS
Type
Article
Abstract
We report here the first elastically bendable single-component pharmaceutical crystal, celecoxib. Interlocked molecular packing without the slip plane and the presence of an isotropic hydrogen bond network are major structural features responsible for both the exceptional elastic flexibility and high stiffness of the celecoxib crystal as revealed by bending and nanomechanical studies. The molecular model of the exceptional elasticity is rationalized by the inhomogeneous spatial separations of molecules in the bent crystal, which is further confirmed by micro-Raman spectroscopy. The celecoxib crystal, exhibiting both therapeutic effects and elastic mechanical behavior, could be used to manufacture functional microdevices with novel medical applications.
Keywords
Description
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
10.1021/acs.chemmater.9b00040
Previously Published Citation
Other identifiers
Suggested citation
Sun, Changquan C.; Wang, Kunlin; Mishra, Manish. (2019). Exceptionally Elastic Single-Component Pharmaceutical Crystals. Retrieved from the University Digital Conservancy, 10.1021/acs.chemmater.9b00040.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.