Studying vascular smooth muscle cell characteristics using an alternating-substrate modulus system
2015-05-14
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Studying vascular smooth muscle cell characteristics using an alternating-substrate modulus system
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2015-05-14
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Abstract
Cardiovascular
diseases
resulting
from
atherosclerosis
comprise
the
single
biggest
cause
of
death
in
the
developed
world1.
In
atherosclerosis,
both
local
vessel
stiffness
and
extracellular
organization
is
perturbed.
Vascular
smooth
muscle
cell
(VSMC)
function
is
perturbed
in
atherosclerosis,
but
it
is
not
clear
if
this
is
due
to
the
evolving
changes
in
extracellular
mechanical
stimuli.
Here,
we
will
build
upon
previous
work
using
microfabrication
techniques
to
determine
the
influence
of
extracellular
matrix
(ECM)
mechanics
and
ECM
organization
on
VSMC
self-‐
organization.
We
will
use
our
previously
developed
alternating-‐substrate
modulus
system
combined
with
microcontact
printing
(MCP)
to
observe
and
quantify
cell
self-‐organization
when
cells
are
guided
by
both
the
stiffness
of
the
underlying
substrate
and
stamped
lines
of
fibronectin
protein.
This
study
will
provide
insight
on
VSMC
behavior
with
competing
influences
on
cell
self-‐organization
and
may
help
provide
insight
to
cell
characteristics
that
may
be
useful
in
developing
atherosclerosis
therapies.
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Becicka, Austin. (2015). Studying vascular smooth muscle cell characteristics using an alternating-substrate modulus system. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/193210.
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