Atypical Activation of Laryngeal Somatosensory-Mmotor Cortex during Vocalization in People with Unexplained Chronic Cough

Title

Atypical Activation of Laryngeal Somatosensory-Mmotor Cortex during Vocalization in People with Unexplained Chronic Cough

Published Date

2023

Publisher

Type

Presentation

Abstract

Importance: Chronic cough (CC) affects up to 10% of the general population, yet its etiology is not well understood. Enhancing our understanding of how peripheral and central neural processes contribute to CC is essential for treatment design. Objective: Determine whether people with CC exhibit signs of abnormal neural processing over laryngeal sensorimotor cortex during voluntary laryngeal motor activity such as vocalization. Design: The study followed a cross-sectional design. In a single visit, electroencephalographic signals were recorded from people with CC and healthy controls during voice production. Participants: A convenience sample of 13 individuals with chronic cough and 10 healthy age-matched controls participated. Outcome Measures: 1) Event-related spectral perturbation over the laryngeal area of somatosensory-motor cortex between 0-30 Hz. 2) Event-related coherence as a measure of synchronous activity between somatosensory and motor cortical regions. Results: In the CC group, the typical movement-related desynchronization over somatosensory-motor cortex during vocalization was significantly reduced across theta, alpha and beta frequency bands when compared to the control group. Conclusions and Relevance: The typical movement-related suppression of brain oscillatory activity during vocalization is weak or absent in people with chronic cough. Thus, chronic cough affects sensorimotor cortical activity during the non-symptomatic, voluntary activation of laryngeal muscles.

Keywords

Description

Related to

Replaces

License

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Xu, Jiapeng; Misono, Stephanie; Kang, Jason; Oh, Jinsok; Konczak, Jürgen. (2023). Atypical Activation of Laryngeal Somatosensory-Mmotor Cortex during Vocalization in People with Unexplained Chronic Cough. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/256004.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.