Investigation of the Novel Peptide TUF1 in Context Conditioning

Abstract

• TUF1 is a newly discovered peptide expressed in the hippocampus, amygdala, hypothalamus, and endocrine tissues (Figure 1B). These regions are crucial for the integration of external stimuli and play an important role in necessary responses for survival, such as fear acquisition to environments. •This study will measure the role of TUF1 in context and will measure whether TUF1 expression is altered after contextual conditioning. •Figure 1A shows the predicted structure of TUF1. Illustrated is the signal peptide (SP) and transmembrane region (TM). •TUF has a p75 receptor-binding domain, a domain commonly found in neurotrophins such as brain-derived neurotrophic factor (BDNF). This indicates that TUF1 could have possible effects on neuronal plasticity.