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Hemodynamics in a giant intracranial aneurysm characterized by in vitro 4D flow MRI

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2016-06-17
2016-12-13

Date completed

2017-12-05

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Journal Title

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Title

Hemodynamics in a giant intracranial aneurysm characterized by in vitro 4D flow MRI

Published Date

2017-12-08

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Author Contact

Coletti, Filippo
fcoletti@umn.edu

Type

Dataset
3D Imaging Data
Experimental Data

Abstract

Experimental and computational data suggest that hemodynamics play a critical role in the development, growth, and rupture of cerebral aneurysms. The flow structure, especially in aneurysms with a large sac, is highly complex and three-dimensional. Therefore, volumetric and time-resolved measurements of the flow properties are crucial to fully characterize the hemodynamics. In this study, phase-contrast Magnetic Resonance Imaging is used to assess the fluid dynamics inside a 3D-printed replica of a giant intracranial aneurysm, whose hemodynamics was previously simulated by multiple research groups. The physiological inflow waveform is imposed in a flow circuit with realistic cardiovascular impedance. Measurements are acquired with sub-millimeter spatial resolution for 16 time steps over a cardiac cycle, allowing for the detailed reconstruction of the flow evolution. Moreover, the three-dimensional and time-resolved pressure distribution is calculated from the velocity field by integrating the fluid dynamics equations, and is validated against differential pressure measurements using precision transducers. The flow structure is characterized by vortical motions that persist within the aneurysm sac for most of the cardiac cycle. All the main flow statistics including velocity, vorticity, pressure, and wall shear stress suggest that the flow pattern is dictated by the aneurysm morphology and is largely independent of the pulsatility of the inflow, at least for the flow regimes investigated here. Comparisons are carried out with previous computational simulations that used the same geometry and inflow conditions, both in terms of cycle-averaged and systolic quantities.

Description

The attached file "giant_ane_velocity_pressure_public_release.tar.gz" contains the processed data for the associated paper.

Referenced by

Amili, O., Schiavazzi, D., Moen, S., Jagadeesan, B., Vande Moortele, P-F., & Coletti, F. (2018). Hemodynamics in a giant intracranial aneurysm characterized by in vitro 4D flow MRI. PLoS One, 13(1), e0188323.
https://doi.org/10.1371/journal.pone.0188323

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Winston and Maxine Wallin Neuroscience Discovery Fund

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Suggested citation

Amili, Omid; Schiavazzi, Daniele; Moen, Sean; Jagadeesan, Bharathi; Van de Moortele, Pierre-François; Coletti, Filippo. (2017). Hemodynamics in a giant intracranial aneurysm characterized by in vitro 4D flow MRI. Retrieved from the Data Repository for the University of Minnesota (DRUM), https://doi.org/10.13020/D6WX0S.

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