Developing wipe sampling strategy guidance for assessing environmental contamination of antineoplastic drugs
2022-08
Loading...
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Developing wipe sampling strategy guidance for assessing environmental contamination of antineoplastic drugs
Published Date
2022-08
Publisher
SAGE
Type
Article
Abstract
Surveillance for environmental contamination of antineoplastic drugs has been recommended by authoritative bodies
such as the United States Pharmacopeia and the National Association of Pharmacy Regulatory Authorities. Clear guidance
is needed on how to develop sampling strategies that align with surveillance objectives efficiently and effectively. We con-
ducted a series of simulations using previously collected surveillance data from nine cancer treatment centers to evaluate
different sampling strategies. We evaluated the impact of sampling 2, 5, 10, or 20 surfaces, at monthly, quarterly, semi-
annual, and annual frequencies, while employing either a random or sentinel surface selection strategy to assess contam-
ination by a single antineoplastic drug (AD) or by a panel of three ADs. We applied two different benchmarks: a binary
benchmark of above or below the limit of detection and AD-specific hygienic guidance values, based on 90th percentile
values as quantitative benchmarks. The use of sentinel surfaces to evaluate a three-drug panel relative to 90th percentile
hygienic guidance values (HGVs) resulted in the most efficient and effective surveillance strategy.
Description
Related to
Replaces
License
Collections
Series/Report Number
Funding information
The author(s) disclosed receipt of the following financial support
for the research, authorship, and/or publication of this article:
This work was supported by the Alberta Health Services (grant
number 095233754)
Isbn identifier
Doi identifier
0.1177/10781552221118535
Previously Published Citation
Arnold S, Jeronimo M, Astrakianakis G, et al. Developing wipe sampling strategy guidance for assessing environmental contamination of antineoplastic drugs. Journal of Oncology Pharmacy Practice. August 2022. doi:10.1177/10781552221118535
Suggested citation
Arnold, Susan; Jeronimo, Matthew; Astrakianakis, George; Kunz, Miranda; Petersen, Ashley; Chambers, Carole; Malard Johnson, Darcy; Zimdars, Emily; Davies, Hugh W. (2022). Developing wipe sampling strategy guidance for assessing environmental contamination of antineoplastic drugs. Retrieved from the University Digital Conservancy, 0.1177/10781552221118535.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.