LYVE1+ Macrophages Regulate Collagen Content in the Mitral Valve
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
LYVE1+ Macrophages Regulate Collagen Content in the Mitral Valve
Published Date
2022-08-03
Publisher
Type
Other
Abstract
Regulation of cardiac extracellular matrix (ECM) is crucial to an organism’s overall health. Valvular ECM composition is important because valves maintain blood pressure and direction of flow. If the mitral valve becomes inflexible, it decreases blood flow in the body. Valvular stability and flexibility necessitate ECM proteins such as collagen, which must be regulated. Without regulation, a buildup of ECM proteins can occur. Many essential cardiovalvular regulatory mechanisms are poorly understood. However, regulation of collagen by specialized resident macrophages has been seen in arteries. Hyaluronan receptors (LYVE1) are present on specialized macrophages that, when bound, release matrix metalloproteinases (MMPs) that proteolyse collagen. To further our understanding on valvular flexibility, we used cross-sections of mitral valves from Lyve1-cre x Csf1r-floxed mouse models to compare mice with LYVE1+ macrophages to mice with depletion of LYVE1+ macrophages. We hypothesized that when LYVE1+ macrophages are depleted, there will be increased collagen content in the mitral valve. We found through picrosirius red staining and analysis that mice with LYVE1+ macrophages contain less collagen in the mitral valve when compared to mice where LYVE1+ macrophages were depleted. This indicates that LYVE1+ macrophages assist in the maintenance of ECM composition.
Keywords
Description
Poster reporting findings on LYVE1 macrophages in the mitral valve. LYVE1 macrophages were shown to significantly regulate collagen content.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Peck, Alyssa L; Binstadt, Bryce; Osinski, Victoria; Auger, Jennifer; Farager, Jessica. (2022). LYVE1+ Macrophages Regulate Collagen Content in the Mitral Valve. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/241667.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.