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Datasets to test the importance of genetic architecture in marker selection decisions for genomic prediction

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Datasets to test the importance of genetic architecture in marker selection decisions for genomic prediction

Published Date

2023-03-01

Author Contact

Hirsch, Candice N
cnhirsch@umn.edu

Type

Dataset
Genomics Data
Simulation Data

Abstract

This dataset contains the input files to simulate traits for maize recombinant inbred lines (RILs) and run genomic prediction models with different marker types. Using real genotypic information from 333 maize recombinant inbred lines with single nucleotide polymorphism (SNP) and structural variant (SV) information projected from their seven sequenced parental lines, we simulated traits with different genetic architectures in multiple environments using the R package simplePHENOTYPES. We varied the heritability, the number of quantitative trait loci (QTLs), the type of causative variant (SNPs or SVs), and the variant effect sizes. Weather data from five locations in the U.S. Midwest in 2020 was used to generate a residual correlation matrix among environments. After performing a two-stage analysis with multivariate GBLUP prediction model for each marker type and genetic architecture, we obtained prediction accuracies using two types of cross-validation (CV1 and CV2). For instructions on how to perform this analysis and analysis script, please see https://github.com/HirschLabUMN/genomic_prediction_svs

Description

Files include structural variant calls of the maize parental lines, genotypic data for recombinant inbred lines (RILs), simulated trait values for each RIL with different genetic architectures, input data for genomic prediction models with different marker types, and genomic prediction accuracy for each combination of simulated genetic architecture and predictors. More detailed information for each file can be found in the README file.

Referenced by

Della Coletta, R., Fernandes, S.B., Monnahan, P.J. et al. (2023). Importance of genetic architecture in marker selection decisions for genomic prediction. Theoretical and Applied Genetics 136, 220.
https://doi.org/10.1007/s00122-023-04469-w

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https://hdl.handle.net/11299/252793.1

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United States Department of Agriculture (2018-67013-27571)
National Science Foundation (IOS-1546727)
Minnesota Agricultural Experiment Station

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Della Coletta, Rafael; Fernandes, Samuel B; Monnahan, Patrick J; Mikel, Mark A; Bohn, Martin O; Lipka, Alexander E; Hirsch, Candice N. (2023). Datasets to test the importance of genetic architecture in marker selection decisions for genomic prediction. Retrieved from the Data Repository for the University of Minnesota (DRUM), https://doi.org/10.13020/atq4-1b58.

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