The efficacy of imiquimod 5% cream (Aldara) in the treatment of aural plaque in horses: a pilot open-label clinical trial
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The efficacy of imiquimod 5% cream (Aldara) in the treatment of aural plaque in horses: a pilot open-label clinical trial
Published Date
2010
Publisher
Veterinary Dermatology
Type
Article
Abstract
Aural plaques affect at least 22% of horses and can be asymptomatic or cause ear sensitivity. Immunohistochemical and electron microscopy studies have
shown a strong association between aural plaques and papilloma virus. The purpose of this study was to investigate the efficacy of imiquimod 5% cream,
an immune response modifier with potent antiviral activity, in the treatment of equine aural plaques. Twenty-one horses were enrolled and 16 completed
the study. Imiquimod 5% cream was applied three times a week, every other week. When both ears were affected only the worst affected ear was treated. Adverse effects in all horses included marked local inflammation, exudation and thick crust formation at the site of treatment and the adjacent skin.
Removal of the crust before treatment was painful and required sedation in most horses. Complete resolution of lesions was noted in all horses immediately post-treatment and the long-term resolution rate was 87.5%. Duration of therapy ranged from 1.5 to 8 months (median: 2.9 mean: 3.5). All horses were followed-up for 12–22 months after treatment was discontinued and only two horses had a recurrence of lesions. Clinical signs related to the aural plaques prior to treatment were reported in 11 of 16 (68.8%) horses and included resistance to touching the ears and bridling. Complete resolution of these signs was reported by the owners in all of the horses followedup for at least 12 months. In conclusion, the topical application of imiquimod 5% cream is an efficacious treatment for aural plaques in horses.
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This is the peer reviewed version of the following article: The efficacy of imiquimod 5% cream (Aldara ® ) in the treatment of aural plaque in horses: a pilot open‐label clinical trial Torres, Sheila M. F. ; Malone, Erin D. ; White, Stephen D. ; Koch, Sandra N. ; Watson, Johanna L. Veterinary Dermatology, October 2010, Vol.21(5), pp.503-509, which has been published in final form at https://onlinelibrary-wiley-com.ezp1.lib.umn.edu/doi/epdf/10.1111/j.1365-3164.2009.00877.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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This project was supported by the University of Minnesota Equine Center, College of Veterinary Medicine, University of Minnesota,
with funds provided by the Minnesota Racing Commission, Minnesota Agricultural Experimental Station, and contributions
from private donors.
Imiquimod was generously donated by 3M Pharmaceutical
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Doi identifier
10.1111/j.1365-3164.2009.00877.x
Previously Published Citation
The efficacy of imiquimod 5% cream (Aldara ® ) in the treatment of aural plaque in horses: a pilot open‐label clinical trial Torres, Sheila M. F. ; Malone, Erin D. ; White, Stephen D. ; Koch, Sandra N. ; Watson, Johanna L. Veterinary Dermatology, October 2010, Vol.21(5), pp.503-509
Suggested citation
Torres, Sheila MF; Malone, Erin D; White, Stephen D; Koch, Sandra N; Watson, Johanna L. (2010). The efficacy of imiquimod 5% cream (Aldara) in the treatment of aural plaque in horses: a pilot open-label clinical trial. Retrieved from the University Digital Conservancy, 10.1111/j.1365-3164.2009.00877.x.
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