Data supporting: Evaluation of neurobehavioral abnormalities and immunotoxicity in response to oral imidacloprid exposure in domestic chickens (Gallus callus domesticus)

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https://doi.org/10.13020/s0ev-vr77
https://hdl.handle.net/11299/219612

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Keywords

Avian toxicity

behavioral toxicology

neurotoxicity

neonicotinoids

risk assessment

Collection period

2017-04-21
2017-08-16

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Data supporting: Evaluation of neurobehavioral abnormalities and immunotoxicity in response to oral imidacloprid exposure in domestic chickens (Gallus callus domesticus)

Published Date

2021-05-10

Authors

Franzen-Klein, Dana M

Jankowski, Mark

Roy, Charlotte L

Nguyen-Phuc, Hoa

Chen, Da

Neuman-Lee, Lorin

Redig, Patrick

Ponder, Julia

Group

The Raptor Center

Author Contact

Franzen-Klein, Dana M
franz337@umn.edu

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Dataset

Abstract

Domestic chickens (Gallus gallus domesticus) were exposed to imidacloprid by gavage once daily for 7 consecutive days at 0, 0.03, 0.34, 3.42, 10.25, and 15.50 mg/kg/day (n = 20 per group; 5 6-week-old males, 5 6-week-old females, 5 9-week-old males, and 5 9-week-old females). The severity and duration of neurobehavioral abnormalities were recorded. Components of the innate and adaptive immune system were assessed with 7 standard functional assays. Temporary neurobehavioral abnormalities were observed in a dose-dependent manner, including muscle tremors, ataxia, and depressed mentation. The effective dose value for the presence of any neurobehavioral abnormalities in 50% of the test group (ED50) was 4.62 ± 0.98 mg/kg/day. The ED50 for an adjusted score that included both the severity and duration of neurobehavioral abnormalities was 11.24 ± 9.33 mg/kg/day. These ED50 values are equivalent to a 1 kg bird ingesting 29 or 70 imidacloprid treated soybean seeds respectively. Immunotoxicity was not documented, either because the assays were insensitive, did not test relevant immune functions, or imidacloprid is not immunotoxic at this dosing schedule in this species. Neurobehavioral abnormalities were a more sensitive indicator of the sublethal effects of imidacloprid than immunotoxicity.

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Published research (full-text): Evaluation of neurobehavioral abnormalities and immunotoxicity in response to oral imidacloprid exposure in domestic chickens (Gallus callus domesticus). 2020, Journal of toxicology and environmental health part A.
https://hdl.handle.net/11299/220100

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CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/

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Data Repository for U of M (DRUM)

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Minnesota Environment and Natural Resources Trust Fund as recommended by the Legislative-Citizen Commission on Minnesota Resources (LCCMR)

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Franzen-Klein, Dana M; Jankowski, Mark; Roy, Charlotte L; Nguyen-Phuc, Hoa; Chen, Da; Neuman-Lee, Lorin; Redig, Patrick; Ponder, Julia. (2021). Data supporting: Evaluation of neurobehavioral abnormalities and immunotoxicity in response to oral imidacloprid exposure in domestic chickens (Gallus callus domesticus). Retrieved from the University Digital Conservancy, https://doi.org/10.13020/s0ev-vr77.

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