Intracellular trafficking of opioid receptor subtypes in response to ligand activation
2012-04-18
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Intracellular trafficking of opioid receptor subtypes in response to ligand activation
Authors
Published Date
2012-04-18
Publisher
Type
Presentation
Abstract
Opioids are currently the most powerful medications available for the treatment of
severe pain. Unfortunately, their strong analgesic capabilities are complicated by
the risk of tolerance, dependence, and abuse. Previous studies have modeled
drug addiction as a pathological form of experienced-based learning. Opioids
have profound effects on the stability of dendritic spines, which are believed to be
important in learning and memory. The internalization of opioid receptors following
ligand binding positively influence the stability of dendritic spines. The present
study examined whether different opioid receptor subtypes could be induced to
internalize following administration of a ‘non-internalizing’ agonist, such as
morphine.
Keywords
Description
Mentor: Ping-Yee Law
Related to
Replaces
License
Series/Report Number
Funding information
This research was supported by the Undergraduate Research Opportunities Program (UROP).
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
McGarrah, Patrick. (2012). Intracellular trafficking of opioid receptor subtypes in response to ligand activation. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/123349.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.