Neural Indicator of Altered Mismatch Detection Predicts Atypical Cognitive-Perceptual Experiences in Psychotic Psychopathology
2022-07
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Neural Indicator of Altered Mismatch Detection Predicts Atypical Cognitive-Perceptual Experiences in Psychotic Psychopathology
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2022-07
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Abstract
Background: Atypical auditory processing (AAP) in psychotic psychopathology is evident in early (N1), mid-latency(P2/N2/mismatch negativity), and late (P3) neural responses.
The influence of attention on AAP, and how temporal stages
of AAP are associated with phenomenology of psychotic
psychopathology are not well understood. Methods: We
used a directed attention oddball task to characterize stages
of AAP in psychosis and to examine the influence of selective attention. Ninety patients with schizophrenia (SCZ), 53
patients with bipolar disorder (BP), 90 healthy controls and
72 first-degree relatives of SCZ (SREL) were studied. We
used principal components analysis to decompose averagereference 64-channel subject-level ERPs. Results: Altered attentional modulation was evident in SCZ at early (N1 factor)
and late (P3 factor) stages of AAP, but not at mid-latency
P2 factor. Irrespective of condition, N1 and P3 were reduced
in SCZ, which predicted greater psychopathology and schizotypal personality traits. Diminished mid-latency mismatch
detection (P2 factor) was evident in SCZ, BP, and SREL and
was associated with greater positive symptoms of psychosis
as well as self-reported atypical cognitive-perceptual experiences. Conclusions: Attentional modulation of early N1, and
later P3 neural responses was atypical in patients, but the
degree of attentional modulation did not relate to symptom
severity or schizotypal traits. Our findings suggest the link
between mid-latency mismatch detection and atypical cognitive/perceptual experiences is not driven by attentional deficits
alone and point to the promise of mid-latency mismatch detection as a candidate endophenotype and intervention target.
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University of Minnesota M.A. thesis. July 2022. Major: Psychology. Advisors: Angus MacDonald, Scott Sponheim. 1 computer file (PDF); iv, 27 pages.
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Pokorny, Victor. (2022). Neural Indicator of Altered Mismatch Detection Predicts Atypical Cognitive-Perceptual Experiences in Psychotic Psychopathology. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/250021.
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