Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) and MATLab scripts for the chemical shift analysis
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December 2018
December 2018
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Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) and MATLab scripts for the chemical shift analysis
Published Date
2020-11-23
Author Contact
Veglia, Gianluigi
vegli001@umn.edu
vegli001@umn.edu
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Experimental Data
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Abstract
Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) and MatLab scripts used for the CHESCA and CONCISE analysis. The chemical shift lists were obtained using standard NMR experiments (1H-15N -TROSY-HSQC). The MatLab scripts were used for the CHESCA and CONCISE analysis of the amide chemical shift. These files are part of a publication on Communication biology: "Defective Internal Allosteric Network Imparts Dysfunctional ATP/Substrate Binding Cooperativity in Oncogenic Chimera of Protein Kinase A"
Description
Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) in the apo form, ATPgN- and ATPgN/PKI-form. The list files were obtained using standard 1H-15N -TROSY-HSQC NMR experiments on uniformly 15N labeled-protein.
The MatLab scripts (coded by Manu) are used for the CHEmical Shift Covariance Analysis(CHESCA) and COordiNated ChemIcal Shifts bEhavior (CONCISE) analysis of the amide chemical shift and their variants like the communtyCHESCA and the communityCONCISE.
Referenced by
Defective Internal Allosteric Network Imparts Dysfunctional ATP/Substrate Binding Cooperativity in Oncogenic Chimera of Protein Kinase A.
https://dx.doi.org/10.1038%2Fs42003-021-01819-6
https://dx.doi.org/10.1038%2Fs42003-021-01819-6
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NIH GM 100310 to G.V
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Veglia, Gianluigi; Olivieri, Cristina; Walker, Caitlin; Veliparambil Subrahmanian, Manu. (2020). Proton and amide chemical shift list files of wild-type cAMP-dependent protein kinase a (PKA-C) and the chimeric mutant (PKA-JC) and MATLab scripts for the chemical shift analysis. Retrieved from the Data Repository for the University of Minnesota (DRUM), https://doi.org/10.13020/7DB9-VD97.
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CHESCA.m
Chemical shift list file
(16.73 KB)
CONCISE.m
MatLab script for CONCISE analysis
(16.74 KB)
Chemical_Shifts_list_file.rar
Chemical shift list file
(49.55 KB)
Domain_and_community_CHESCA.m
Domain&Community-CHESCA
(8.33 KB)
deCONCISE.m
Domain&Community-CONCISE
(9.81 KB)
Readme.txt
Readme
(6.68 KB)
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