Fungal species are highly prevalent in our environment. Some are relatively harmless but there are others that are pathogenic. A problem arises when dermatophytes enter into the blood system. Commonly associated with immunocompromised patients, fungemia is when a fungal species enters the blood stream. Currently there are many treatments but there is a growing fear of resistance to these drugs and a need for novel therapeutics. The Baylis-Hillman reaction is a flexible template in which an aldehyde and various acrylates form a highly functionalized Baylis-Hillman derivative. In this paper, a small library of Baylis-Hillman reaction-derived imidazole and triazoles are synthesized and characterized. Furthermore, their anti-fungal activities are evaluated against <italic>Candida albicans</italic> and <italic>Cryptococcus neoformans</italic>. It was found that some of the derivatives showed moderate to good activity against <italic>Candida albicans</italic> (MIC 213-46.5 µg/ml) and <italic>Cryptococcus neoformans</italic> (MIC 5.50-1.68 µg/ml).
University of Minnesota M.S. thesis. September 2014. Major: Chemistry. Advisor: Venkatram Mereddy. 1 computer file (PDF); vii, 163 pages.
Synthesis and Evaluation of Functionalized Imidazole and Triazoles as Novel Anti-fungal Agents.
Retrieved from the University of Minnesota Digital Conservancy,
Content distributed via the University of Minnesota's Digital Conservancy may be subject to additional license and use restrictions applied by the depositor.