Browsing by Subject "warfarin"

Now showing 1 - 5 of 5
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    Assessment of patient perceptions concerning a community pharmacy-based warfarin monitoring service
    (University of Minnesota, College of Pharmacy, 2012) Waitzman, Jennifer; Hiller, Debbie Pruss; Marciniak, Macary Weck; Ferreri, Stefanie
    Objective: To assess patient perceptions of a North Carolina community pharmacy-based warfarin monitoring service. Methods: Prospective study of patients 18 years of age and older, who filled a prescription for warfarin, in one of five Raleigh area community pharmacies, between May 1, 2010 and October 31, 2010. A 14 item survey, along with a self-addressed stamped envelope, was mailed to 330 identified patients. The survey inquired about details of current anticoagulation monitoring services, interest in utilizing a local community pharmacy for this service, and confidence in a pharmacist-managed program. Results: 26% of surveys were returned. 48% of surveyed individuals responded that they would be interested in having their warfarin monitoring performed by a trained pharmacist in a community pharmacy setting. Conclusion: Many participants responded that the community pharmacy would be more convenient than or as convenient as their current location. This may be a new clinical service that could be offered in certain community pharmacies.
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    Atrial Fibrillation: Prevention of Strokes
    (2009-09-18) Anderson, Sarah
    Atrial fibrillation is the most common arrhythmia seen in the clinical setting. This so called, irregularly irregular rhythm is associated with thrombosis, or clot formation, in the heart. These clots have the potential to break free and travel to different places in the body, including the brain. Clots traveling to the brain prevent adequate circulation, resulting in a stroke. This pamphlet describes atrial fibrillation, why it has the increased potential to form thromboses, which patients are at increased risks of strokes, and the treatment options including antithrombotic therapies.
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    Bridging to Warfarin - A Patient's Guide to Low-Molecular-Weight Heparin
    (2009-08-20) Luger, Alex
    A patient's guide to bridging to warfarin. LMWH dosed once daily is as safe and effective as LMWH dosed twice daily, and is important for preventing the increased risk of clotting that occurs when first starting warfarin.
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    Facts about stroke prevention
    (2008-12-01) Anderson, Kristin
    Stroke represents a heavy burden of disease in the US; it is the third leading cause of death. The risk of stroke after a first cerebrovascular event is high; annual estimates range from 4-11% in this population. Primary stroke prevention encompasses a variety of lifestyle changes such diet change, exercise, smoking cessation, and moderation of alcohol intake. The goal of these actions is to prevent conditions associated with an increased risk of stroke, including hypertension, hyperlipidemia, and diabetes. Once a patient has had a stroke, pharmacotherapy is indicated for prevention of recurrence. Studies thus far indicate that in patients with normal heart rhythms, antiplatelet therapy with aspirin is the best choice for reducing risk of another stroke. Patients with heart rhythms such as atrial fibrillation should be on oral anticoagulation therapy with warfarin.
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    Quantitative Methods for Evidence Building in Clinical Pharmacology and Pharmaceutical Outcomes Research
    (2021-05) Margraf, David
    A variety of methods are employed to build evidence in pharmacology and pharmaceutical outcomes research. Descriptive and inferential statistics are used to describe the data and generalize findings to populations. Regression models, propensity score adjustment, and meta-analysis extend upon the quantitative approach to building evidence. Topic areas in this dissertation include demonstrating the application of these methods to a comparison of three-factor prothrombin complex concentrate versus four-factor prothrombin complex concentrate for emergent warfarin reversal via a propensity score adjusted retrospective cohort study and a systematic review and meta-analysis to address clinical problems and improve health outcomes. Also presented are the pharmacokinetics of intravenous N-acetylcysteine, Cysteine, and Glutathione and the effect of N-acetylcysteine as a reducing agent in Parkinson’s disease and Gaucher disease. While quantitative methods help us explore, explain, and generalize from data, it is imperative to consider the clinical relevance of the findings. We found that four-factor prothrombin complex concentrate is preferred for emergent warfarin reversal. This is a finding is useful in real-world patient care. Also, increased N-acetylcysteine plasma concentrations and Glutathione redox ratio are related, which could be used to optimize dosing in future studies. These examples are described in detail as examples of applications of quantitative methods.