Browsing by Subject "surface electromyography"

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    Acute contraction-induced strength loss, muscle inexcitability and recovery after exercise in males with Duchenne muscular dystrophy
    (2020-11) Trost, Joyceann
    This dissertation had three objectives with the overall goal to explore contraction-induced strength loss and recovery in males with Duchenne muscular dystrophy (DMD) specifically to: 1) evaluate a novel protocol, combining voluntary and evoked contractions to measure strength and excitability of wrist extensor muscles, for safety, feasibility, reliability and discriminant validity for males with DMD and aged-matched controls, 2) explore strength loss and muscle fiber inexcitability contribution to strength loss after submaximal isometric contractions in males with DMD, and. 3) determine the recovery of strength and muscle excitability immediately following contraction-induced force loss in males with DMD. Through the literature review, I discovered a need for a reliable and valid measurement protocol of muscle contractile function that could be used for DMD across all disease levels. Several measures for walking and upper extremity function are currently used to measure outcomes during clinical trials. However, none of the current measurements for DMD incorporate a way to quantitatively measure both voluntary and evoked strength along with muscle excitability over disease progression or in response to an intervention. The key to the assessment and protocol design needed to be feasibility and safety for boys and men with DMD at different stages of the disease process. I was able to design and evaluate a novel protocol, combining voluntary and evoked contractions to measure strength and excitability of wrist extensor muscles for safety, feasibility, reliability and discriminant validity between males with DMD and controls (Chapter 3). Wrist extensor muscle strength and excitability were assessed in males with DMD (N=10; mean 15.4 [SD 5.9] years) (Brooke 1-6) and age-matched healthy male controls (N=15; mean 15.5 [SD 5.0] years). Torque and EMG measurements were analyzed under maximum voluntary and stimulated conditions at two visits. I discovered that our protocol of multiple maximal voluntary contractions (MVC) and evoked twitch contractions was feasible and safe, with 96% of the participants able to complete the assessment protocol maintaining >93% strength both for DMD and controls (P≥0.074). Reliability was excellent for voluntary and evoked measurements. Torque, EMG and timing of twitch onset measurements discriminated between DMD and controls (P<0.001). This first part of the study demonstrated a useful protocol for measuring skeletal muscle function in clinical trials in males with DMD across various ages and disease levels. The second part of the study addressed in the context of a neuromuscular disease the concern of injury to dystrophic deficient skeletal muscle during and after repeated contractions (exercise) that result in acute strength loss. I knew that a feature of dystrophin-deficient skeletal muscle in the mdx mouse model was a hypersensitivity to strength loss from eccentric exercise due to fibers becoming unexcitable. I wanted to explore how this feature translated to humans lacking dystrophin. We hypothesized that there would be no difference in strength loss during exercise and that males with Duchenne muscular dystrophy (DMD) would have more significant impairment in muscle excitability corresponding with a loss of strength than age-matched controls (Chapter 4). Males with DMD and a group of age-matched controls performed a sub-maximal voluntary isometric wrist extensor exercise protocol until 55% of maximal voluntary contraction (MVC) could no longer be sustained. Voluntary and evoked force and EMG were accessed before, during, and after exercise. There was a significant interaction (time*group) (p<0.001) for MVC torque during exercise, suggesting that the two groups were different in how they reached muscle fatigue. No difference was measured between groups in MVC torque decrement at the time of exercise cessation (by design). Evoked twitch torque decrement was 34% for DMD and 36% for control with no group*time interaction observed (p=0.834). Muscle excitability contributed to the evoked torque variance in DMD (76%) and control (59%). The groups were not different in RMS EMG decrement (P=0.986) or M-wave decrement (P=0.911) during exercise, which does not support our hypothesis that the DMD groups had a more considerable decline in muscle excitability with fatigue during exercise. Lastly, the recovery of both strength and muscle excitability was explored and compared between groups. The DMD group recovered MVC baseline strength by 10 minutes post-exercise (P=0.530) and evoked torque by 5 minutes (P=0.266). In contrast, controls were still different from MVC and evoked torque baseline at 15 minutes after exercise (P<0.002). Strength loss from submaximal intermittent isometric exercise does not result in more significant impairment of muscle excitability is transient, and recovers faster in males with DMD than controls, suggesting a different mechanism of peripheral fatigue between the groups. The work contained in my dissertation begins to address the fear of exercise that has been a common concern for individuals with DMD and will contribute to knowledge of evidence-based exercise prescription in the future.
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    Vibro-tactile stimulation as a non-invasive neuromodulation therapy for cervical dystonia: a case study
    (2020-07) Zhu, Yi
    Background: Cervical dystonia (CD) is a type of focal dystonia characterized by involuntary neck postures. The underlying neurophysiology mechanism of CD is unknown, but it has been long hypothesized to be associated with somatosensory and proprioceptive deficits. As a form of somatosensory stimulation approach, vibro-tactile stimulation (VTS) is known to alter afferent signals from the vibrated mechanoreceptors in muscles and tactile receptors in the skin. Previous studies have shown that VTS can be an effective neuromodulation therapy for treating laryngeal dystonia. Objectives: This proof-of-concept study examined the effect of VTS on alleviating the involuntary cervical muscle contractions in two adolescents with different presentations of CD – a male with consistent retrocollis and a female intermittent torticollis. Method: VTS was applied sequentially on four neck positions: bilateral trapezius (TRP) and bilateral sternocleidomastoid (SCM). Each VTS site was vibrated continuously for six minutes. The kinematics and underlying neck muscle activities during dystonic neck movements were examined with acceleration and surface electromyography (sEMG). Two acceleration features and two sEMG features were derived: (1) number of peaks per minute; (2) peak amplitude of acceleration (PAA); (3) change in power of sEMG after VTS; (4) cumulative density function of sEMG between 3-10 Hz (CDF10). Results: First, the application of neck muscle VTS did not induce meaningful symptom relief for the participant with constant retrocollis. Second, the frequency of dystonic neck movements decreased by 60% after VTS in the participant who presented with intermittent torticollis. In addition, PAA during dystonic episodes was significantly lower in post VTS when compared to baseline. Third, the effectiveness of VTS in alleviating dystonic muscle spasms depended on the site of vibration. For the patient with right torticollis, the left trapezius muscle was the optimal vibration site reducing sEMG signal power by 15% across all recorded muscles. During VTS on the optimal vibration site, sEMG power of left trapezius dropped rapidly within the first minute and then continued to decline over time. As an additional result, the mean CDF10 of left trapezius in post VTS condition was found significantly lower than baseline. Discussion: This case study offered preliminary insight into the assumed effectiveness of neck muscle VTS as a treatment for CD. One participant responded positively to VTS. The frequency and extent of the dystonic postures were markedly reduced during and immediately after VTS application. A systematic study with larger sample size is required in the future to validate the effectiveness of VTS for treating symptoms in CD.