Browsing by Subject "hormones"

Now showing 1 - 3 of 3
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    Chronic Pelvic Pain in Women – Causes, diagnosis, and treatment
    (2010-07-21) Hieronimus, Ashley M
    Between 4-20 % of women suffer from chronic pelvic pain. This condition is characterized by pain in the lower abdomen that has been going on for longer than six months, that is not directly caused by the menstrual cycle, and interferes with everyday life. It is a condition not a disease. This pamphlet outlines the primary causes of chronic pelvic pain and how these are diagnosed and treated.
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    Estradiol deficiency impairs satellite cell function and causes muscle weakness via an estrogen receptor alpha mediated mechanism
    (2017-12) Collins, Brittany
    Overall, my dissertation work has shown that estradiol is a critical extrinsic factor in females that regulates muscle stem cell (i.e. satellite cell) and skeletal muscle function (Chapters 3 and 4) and estrogen receptor alpha (ER) is the main receptor estradiol utilizes for these functions (Chapters 3 and 4). I identified that the loss of ovarian hormones resulted in impaired satellite cell functions such as maintenance and self-renewal, while estradiol treatment rescued the detrimental effects on satellite cell maintenance and self-renewal (Chapter 3). Further experiments utilized a transgenic mouse that specifically ablated ER in satellite cells, the results of which indicated that ER is necessary for proper satellite cell function (Chapter 3). In agreement with my work on satellite cells, I identified that ER is necessary for overall skeletal muscle function (Chapter 4). I utilized a transgenic mouse model that deleted ER specifically from skeletal muscle fibers which resulted in impairments in strength, power, and fatiguability of skeletal muscle (Chapter 4). The work of my dissertation highlights a novel mechanism for estradiol and ER in skeletal muscle.
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    Identifying The Characteristics Of Slow Growing Pigs And Risk Factors Associated With Slow Growth
    (2015-12) He, Yijie
    Pigs that grow significantly slower than their contemporaries are problematic for animal well-being and profitability. This study was designed to investigate the physiological and behavioral characteristics of slow growing pigs and risk factors associated with slow growth, and to investigate the effect of feeder space on pig performance. The results suggest that light body weights at early stages were the major risk factors for slow growth. Low concentrations of IGF-1, insulin, leptin and total AA were associated with slow growth in pigs. The need to provide ample feeder space during the early stage of growth in order to alleviate slow growth did not appear to be beneficial in growth performance in this study. Providing more feeder space reduced time spent standing, and tended to increase time spent lying by SG pigs, indicating that SG pigs may benefit from more feeder space and have improved welfare.