Browsing by Subject "RNR"

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    Counteraction of APOBEC3 Proteins by Herpesvirus Ribonucleotide Reductases
    (2019-08) Cheng, Adam
    The APOBEC3 family of DNA cytosine deaminases plays an important role in antiviral innate immunity. In this thesis, we describe the novel function of APOBEC3B as a physiologic restriction factor against herpesviruses such as Epstein-Barr virus and herpes simplex virus type 1. We additionally define the counteraction mechanism imparted by herpesviruses using the virus-encoded ribonucleotide reductase large subunit. These viral proteins directly bind A3B to inhibit enzymatic activity, relocalize it away from replicating viral DNA, and protect the virus from A3B-mediated hypermutation for preservation of the viral genome. These results have the potential to reveal new modes of antiviral therapy and have implications in the treatment of A3B-driven cancers.