Counteraction of APOBEC3 Proteins by Herpesvirus Ribonucleotide Reductases
2019-08
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Counteraction of APOBEC3 Proteins by Herpesvirus Ribonucleotide Reductases
Authors
Published Date
2019-08
Publisher
Type
Thesis or Dissertation
Abstract
The APOBEC3 family of DNA cytosine deaminases plays an important role in antiviral innate immunity. In this thesis, we describe the novel function of APOBEC3B as a physiologic restriction factor against herpesviruses such as Epstein-Barr virus and herpes simplex virus type 1. We additionally define the counteraction mechanism imparted by herpesviruses using the virus-encoded ribonucleotide reductase large subunit. These viral proteins directly bind A3B to inhibit enzymatic activity, relocalize it away from replicating viral DNA, and protect the virus from A3B-mediated hypermutation for preservation of the viral genome. These results have the potential to reveal new modes of antiviral therapy and have implications in the treatment of A3B-driven cancers.
Description
University of Minnesota Ph.D. dissertation. August 2019. Major: Microbiology, Immunology and Cancer Biology. Advisor: Reuben Harris. 1 computer file (PDF); xvi, 208 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Cheng, Adam. (2019). Counteraction of APOBEC3 Proteins by Herpesvirus Ribonucleotide Reductases. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/224954.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.