Browsing by Subject "Protein Kinase A"
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Item Cyclic AMP dependent Protein Kinase A (PKA) mutant associated with Fibrolamellar Hepatocellular carcinoma (FLHCC): Structure, dynamics and in cell studies.(2020-03) Karamafrooz, AdakThe overall goal of this thesis is to gain a better understanding of the structure, dynamics and function of PKA-DNAJB1 in vitro and in vivo, using human PKA-WT as reference for the studies. I have utilized NMR for most of structural and dynamics studies, ITC for binding experiments and Phosphoproteomics for in vivo studies.