Cyclic AMP dependent Protein Kinase A (PKA) mutant associated with Fibrolamellar Hepatocellular carcinoma (FLHCC): Structure, dynamics and in cell studies.
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The overall goal of this thesis is to gain a better understanding of the structure, dynamics and function of PKA-DNAJB1 in vitro and in vivo, using human PKA-WT as reference for the studies. I have utilized NMR for most of structural and dynamics studies, ITC for binding experiments and Phosphoproteomics for in vivo studies.
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University of Minnesota Ph.D. dissertation. March 2020. Major: Biochemistry, Molecular Bio, and Biophysics. Advisors: David Thomas, Reuben Harris. 1 computer file (PDF); vi, 148 pages.
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Karamafrooz, Adak. (2020). Cyclic AMP dependent Protein Kinase A (PKA) mutant associated with Fibrolamellar Hepatocellular carcinoma (FLHCC): Structure, dynamics and in cell studies.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/217138.
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