Browsing by Subject "Organic synthesis"

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    Methods for Directed C–O Bond Functionalization of Esters and Acyl Equivalents
    (2022-12) Underwood, Steven
    A summary of work developing and studying the mechanisms of new transition metal-catalyzed acyl transfer reactions using substrates at the ester oxidation state. New methods discussed include steric-controlled arene acylation via sequential C–O/C–H bond activation and a Suzuki-Miyaura cross coupling using N-pyridylimidates as acyl equivalents.
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    Synthesis and Biological Evaluation of Simple Baylis-Hillman Carboxylic Acid Esters as Potential Anticancer Agents
    (2017) Zhang, Yishu; Gibbons, Jake; Hubbard, Skylar; Schumacher, Tanner; Gardner, Zachary
    Baylis Hillman (BH) reaction is important for C-C bond forming reactions in organic synthesis. Allyl alcohols can be synthesized readily by this reaction and these alcohols undergo nucleophilic rearrangement to provide wide range of useful synthons for organic and medicinal chemistry. We are interested in the development of new molecules based on BH reaction and we have initiated this project to explore novel functionalized allyl esters derived from BH reaction as potential anticancer agents. We synthesized several carboxylic acids derived analogs of bromomethyl phenyl acrylate obtained from BH reaction. The allyl ester was further dihydroxylated using OsO4. The synthesized molecules have been evaluated against several cancer cells including triple negative breast cancer cell line MDA-MB-231, and pancreatic cancer cell line MIAPaCa-2. These studies have indicated that several of the synthesized compounds show good cytotoxicity with EC50 values in the range of 3-73μM. Interestingly, the removal of electrophilic double bond in both compounds 2 and 4 reduced the biological activity.