Browsing by Subject "Natural Tregs"

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    Co-stimulation and IL-2 in natural regulatory T cell development.
    (2010-09) Dings, Kieng Bao
    Treg development occurs via a two-step process. In step 1, signals through the T cell receptor and costimulation via CD28 initiate a Treg developmental program that is dependent on the NFkB signaling pathway. Notably, signals through CARMA1 and C-REL initiate a Treg progenitor in which cytokine signaling such as IL-2 (step 2) via STAT5 turns on Foxp3. Herein, we discuss in detail the molecular requirement for natural regulatory T cell development.