Co-stimulation and IL-2 in natural regulatory T cell development.
2010-09
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Co-stimulation and IL-2 in natural regulatory T cell development.
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2010-09
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Treg development occurs via a two-step process. In step 1, signals through the T cell receptor and costimulation via CD28 initiate a Treg developmental program that is dependent on the NFkB signaling pathway. Notably, signals through CARMA1 and C-REL initiate a Treg progenitor in which cytokine signaling such as IL-2 (step 2) via STAT5 turns on Foxp3. Herein, we discuss in detail the molecular requirement for natural regulatory T cell development.
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University of Minnesota Ph.D. dissetation. September 2010. Major: Microbiology, Immunology and Cancer Biology. Advisor: Dr. Michael A. Farrar. 1 computer file (PDF); v, 110 pages. Ill. (some col.)
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Dings, Kieng Bao. (2010). Co-stimulation and IL-2 in natural regulatory T cell development.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/98413.
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