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Browsing by Subject "Medical School"

Now showing 1 - 20 of 204
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    2005 Dean's Report
    (University of Minnesota, 2005) University of Minnesota. Medical School; Powell, Deborah E.
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    2006 Dean's Report
    (University of Minnesota, 2006) University of Minnesota. Medical School; Powell, Deborah E.
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    2007 Dean's Report
    (University of Minnesota, 2007) University of Minnesota. Medical School; Powell, Deborah E.
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    2008 Dean's Report
    (University of Minnesota, 2008) Powell, Deborah E.; University of Minnesota. Medical School
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    2008 Family Medicine Community Report
    (University of Minnesota, 2008) University of Minnesota. Medical School; University of Minnesota. Department of Family Medicine and Community Health
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    AHC Strategic Planning Initiative 2000: Medical School - Clinical Sciences
    (University of Minnesota, 2000) University of Minnesota. Academic Health Center
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    AHC Strategic Planning Initiative 2000: Phase I Report of the Medical School Committee on Basic Research
    (University of Minnesota, 2000) University of Minnesota. Academic Health Center
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    The Biomechanical Puncture Study of the Fossa Ovalis in Human and Porcine Hearts
    (2011-04-13) Balto, Daniel
    About 1 in every 4 adults here in the U.S. has some sort of congenital heart defect, the majority of these defects is caused by a Patent Fossa Ovalis (PFO). It occurs when the hole between the left and right atria (Foramen Ovale) does not close completely at the moment of birth. The study involved designing and then constructing an apparatus to hold an excised heart in proper anatomical position so that the Fossa Ovalis was accessible from both atria of the heart. Once that was accomplished, a catheter type device was designed and then used to measure the force required to puncture the fossa membrane and the data was recorded. Many different factors were analyzed with this data such as fossa morphology and anatomy. The reason for creating such a device for testing fossa strength was to observe if the fixation of the tissue with formalin would change the properties of the fossa in a variety of human and pig hearts that have been preserved in formalin and used as in vivo equivalents. The data gained will allow me to compare how current PFO’s (heart defects) are fixed and what new surgical procedures or biomedical devices can be created based on the strength of the average Fossa Ovalis of a human.
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    A Brief History of the Department of Radiology
    (University of Minnesota, 1967) Kieffer, Stephen; Gedgaudas, Eugene; Peterson, Harold
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    College of Medical Sciences Annual Faculty Dinner, October 8, 1951
    (University of Minnesota, 1951) University of Minnesota. College of Medical Sciences
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    Comparative Analysis of Hs6st and Sulf1-mcherry Expression Patterns in Drosophila
    (2011-04-13) Uk, Samantha; Dang, An
    Heparan sulfate proteoglycans (HSPGs) are molecules that are comprised of a core protein modified with heparan sulfate (HS), a negatively charged linear polysaccharide, consisting of uronic acid and N-acetyl-glucosamine (GlcNAc) disaccharide repeats. Generally, these molecules are located on the cell surface and the extracellular matrix. HSPGs have been known to be associated with various biological processes such as growth factor signaling, neuronal development, and cell adhesion. HS chains possess heterogeneous structures, and their diverse patterns of sulfation can determine the binding specificity for certain proteins. 6-O-sulfation of GlcNAc (or GlcNSO3) is the key modification of HS, since it can be dynamically regulated; heparan sulfate 6-sulfotransferase (Hs6st) catalyzes the transfer of sulfate groups of GlcNAc (or GlcNSO3), while heparan sulfate 6-O endosulfatase (Sulf1) removes it. However, how 6-O-sulfation is regulated during animal development remains largely unknown. In this poster, we will present expression analysis of these enzymes in the fruit fly Drosophila melanogaster. We generated a transgenic reporter fly for Sulf1 gene, and its expression pattern was compared with that of Hs6st gene using Hs6st-lacZ enhancer trapline. Our study will provide regulatory mechanisms of HS during the development of Drosophila as well as other multi-cellular organisms.
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    Cytogenetics Worldwide
    (2012-04-18) Selinger, Jessie
    With the advance of molecular technology in the past thirty years, cytogenetic analysis has become essential for making an appropriate diagnosis, prognosis, and treatment plan for children with acute leukemia. It is now a regular practice to document the frequencies of chromosomal translocations that are found in children with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), but a comparison of the different frequencies of chromosomal translocations throughout the world has not yet been undertaken. Differing frequencies of chromosomal translocations in pediatric leukemia in populations worldwide could have large implications for the study of genetics and pediatric leukemia.
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    Data Concerning the Hospital and Medical School of the University of Minnesota and other State Universities
    (University of Minnesota, 1926) University of Minnesota. University Hospitals and Clinics
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    Diabetes During Pregnancy: a guide for mothers-to-be diagnosed with Gestational Diabetes
    (2011-12-01) Morcomb, Erin
    Gestational Diabetes occurs in pregnant women who have never been diagnosed with diabetes before but who have high blood sugar (glucose) levels during pregnancy. The exact cause is unknown. Some scientists believe that it is caused by hormones released from the placenta, the structure that helps support the baby as it grows inside of its mother. These hormones are important for the baby’s development, but they can also lead to a phenomenon called insulin resistance, which makes it hard for the mother’s body to use insulin even though it is making enough of it. Since insulin is responsible for getting glucose into cells so that it can be used for energy, and since the mother’s body is resistant to it, the sugar builds up in the blood. This is called hyperglycemia, and it can lead to devastating consequences for both the mom and baby.
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    The Effects of Cocaine Abuse on Functional Connectivity within the Mesolimbic Pathway
    (2011-01-19) Henry, David
    With an estimated 1.5 million chronic cocaine users in the U.S., cocaine abuse is a considerable public health concern (Bolla et al., 2004). The mood elevation and euphoria associated with cocaine use is the result of the inhibition of the reuptake of dopamine in the mesolimbic “reward” pathway. Chronic cocaine use produces a number of distinctive biochemical adaptations within structures in this pathway, and has been the focus in numerous studies (Berhow et al 1996). A decrease in functional connectivity (i.e. the level of correlation in neural activity between distinct brain regions) in the primary motor and visual cortexes has been shown to be an acute effect of cocaine intake (Li et al 2000). The long-term effects of chronic cocaine-use on functional connectivity between structures in the mesolimbic pathway, however, has never before been investigated. Resting state functional magnetic resonance imaging (fMRI) enables researchers to observe and analyze spontaneous neural activity since the subject is not performing a task. An index of resting state functional connectivity can be created by cross-correlating activity patterns between each of the brain regions of interest (ROIs).
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    Evaluating the Phagocytosis of Diseased Photoreceptor Outer Segments by Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration
    (2021) Stahl, Madilyn
    Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is characterized by the death of photoreceptors and the retinal pigment epithelium (RPE). One of the main functions of the RPE is to phagocytose photoreceptor outer segments (POS) daily. While lipids in POS are used for energy production in the RPE, this process also produces toxic byproducts that cause oxidative damage. This study used induced pluripotent stem cells (iPSC) differentiated into RPE from a human donor without AMD (n = 1) to investigate whether photoreceptor disease state has an effect on the POS uptake. Results show that POS uptake is not dependent on AMD presence, but the uptake is POS donor specific.
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    Expression of Surfactant Protein-A (SP-A) in the Developing MurineIntestinal Tract
    (2011-04-13) Theisen, Erin
    Surfactant protein-A (SP-A) plays a critical role in the innate immune system and has well characterized effects in the lung where it attenuates inflammatory responses and controls invasion of bacteria. Extra-pulmonary sources of SP-A have also been indentified : SP-A mRNA has been detected in the murine neonatal and adult gastrointestinal (GI) tract, while significant levels of SP-A protein have been detected in amniotic fluid. A novel finding by the George research lab showed that SP-A knockout (-/-) newborn mice raised in a bacterial laden corn dust environment exhibited intestinal inflammation-- instead of pulmonary inflammation--and higher rates of death. Further studies have shown that SP-A -/- mice exhibit abnormal bacterial colonization patterns in the GI tract compared to their wild-type counterparts, indicating a role for SP-A in the newborn intestinal tract. To date it is not clear if newborn intestinal exposure to SP-A comes from ingested amniotic fluid or from production in the newborn intestinal tract. RT-qPCR showed low levels of SP-A gene expression in the newborn murine GI tract; yet, we and others have had mixed results regarding the detection of SP-A protein via immunohistochemistry. To address the question of intestinal exposure of SP-A in the newborn, I will perform RNA in situ hybridization to identify gene expression in specific cells of the GI tract. I have designed a 438 bp digoxigenin-labeled antisense RNA probe specific for the SP-A gene. This probe will be used on flash-frozen GI and lung tissue sections of mice at post-natal days of life 5 and 6 with an in situ hybridization protocol designed by the Panoskaltsis-Mortari laboratory.
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    Family Medicine Connection, April 2009
    (University of Minnesota, 2009-04) University of Minnesota. Medical School; University of Minnesota. Department of Family Medicine and Community Health
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    Family Medicine Connection, April 2010
    (University of Minnesota, 2010-04) University of Minnesota. Medical School; University of Minnesota. Department of Family Medicine and Community Health
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    Family Medicine Connection, August 2008
    (University of Minnesota, 2008-08) University of Minnesota. Medical School; University of Minnesota. Department of Family Medicine and Community Health