Browsing by Subject "Human genomics"

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    Data related to Genetic diversity fuels gene discovery for tobacco and alcohol use
    (2022-10-13) Saunders, Gretchen R B; Wang, Xingyan; Chen, Fang; Jang, Seon-Kyeong; Liu, Mengzhen; Wang, Chen; Liu, Dajiang J; Vrieze, Scott; saund247@umn.edu; Saunders, Gretchen R B
    We conducted a meta-analysis of 60 genome wide association studies (GWAS) in up to 3.4 million participants from four major ancestries on nicotine and substance use. Specifically, we targeted different stages and kinds of substance use from initiation (smoking initiation and age of regular smoking initiation) to regular use (drinks per week and cigarettes per day) to cessation (smoking cessation). Here we present the final set of filtered meta-analysis summary statistics and polygenic risk score weights excluding 23andMe. As per requirement and to ease dissemination of our results for other scientific endeavors, we are sharing our results here to facilitate downloading.