Data related to Genetic diversity fuels gene discovery for tobacco and alcohol use
2022-10-13
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2022-10-12
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Data related to Genetic diversity fuels gene discovery for tobacco and alcohol use
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2022-10-13
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Saunders, Gretchen R B
saund247@umn.edu
saund247@umn.edu
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Genomics Data
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Genomics Data
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Abstract
We conducted a meta-analysis of 60 genome wide association studies (GWAS) in up to 3.4 million participants from four major ancestries on nicotine and substance use. Specifically, we targeted different stages and kinds of substance use from initiation (smoking initiation and age of regular smoking initiation) to regular use (drinks per week and cigarettes per day) to cessation (smoking cessation). Here we present the final set of filtered meta-analysis summary statistics and polygenic risk score weights excluding 23andMe. As per requirement and to ease dissemination of our results for other scientific endeavors, we are sharing our results here to facilitate downloading.
Description
Files include summary statistics for associations with each phenotype: Drinks per week, Cigarettes per day, Smoking initiation, Smoking cessation, and Age of initiation. Details for each file can be found in the readme file or in the article's Supplementary Text.
Referenced by
When using this data, please cite the original publication:
Saunders, G.R.B., Wang, X., Chen, F. et al. Genetic diversity fuels gene discovery for tobacco and alcohol use. Nature 612, 720–724 (2022).
https://doi.org/10.1038/s41586-022-05477-4
Saunders, G.R.B., Wang, X., Chen, F. et al. Genetic diversity fuels gene discovery for tobacco and alcohol use. Nature 612, 720–724 (2022).
https://doi.org/10.1038/s41586-022-05477-4
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R56HG011035, R01DA044283, R01DA042755, U01DA041120,R01GM126479, R56HG011035, R03OD032630, R01HG011035, R56HG012358, T32DA050560
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Saunders, Gretchen R B; Wang, Xingyan; Chen, Fang; Jang, Seon-Kyeong; Liu, Mengzhen; Wang, Chen; Liu, Dajiang J; Vrieze, Scott. (2022). Data related to Genetic diversity fuels gene discovery for tobacco and alcohol use. Retrieved from the Data Repository for the University of Minnesota (DRUM), https://doi.org/10.13020/przg-dp88.
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README.txt
README file
(5.58 KB)
PRS_weights.zip
Polygenic risk score weights
(258.48 MB)
Multi_ancestry.zip
Multi-ancestry summary statistics
(3.69 GB)
MDS_datafiles.zip
Multidimensional scaling data files
(4.77 KB)
EUR_stratified.zip
European ancestry summary statistics
(1.32 GB)
EUR_stratified_without_UKB.zip
European ancestry summary statistics without UK Biobank and 23andMe
(1.35 GB)
AFR_stratified.zip
African ancestry summary statistics
(1.3 GB)
EAS_stratified.zip
East Asian ancestry summary statistics
(782.92 MB)
AMR_stratified.zip
American ancestry summary statistics
(889.95 MB)
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