Browsing by Subject "Department of Physical Medicine and Rehabilitation"
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Item Comparison of Carbonylation in Young and Old Rat Skeletal Muscle(2010-04-21) Brancel, KiaraReactive oxygen species (ROS) are a natural byproduct of aerobic cellular metabolism. They are highly reactive molecules which cause oxidative damage, such as carbonylation, to proteins, lipids and DNA. Because of the high metabolism and energy demand of skeletal muscle, it is especially susceptible to the carbonylation. Thus, the level of carbonylation can be used as a quantitative estimate of the amount of oxidative damage to the tissue.Item The Effect of Estrogen Depletion on Skeletal Muscle Metabolism(2009-04-08) Kosir, Allison M.Skeletal muscle plays a significant role in altering metabolic activity of the body by influencing blood lipid profiles and insulin sensitivity through enzymatic processes. Hormones such as estrogen have been shown to effect skeletal muscle function. Research indicates the metabolic influence of skeletal muscle may be altered by the depletion of estrogen. Through its role in energy metabolism and expenditure, skeletal muscle likely influences the development of cardiovascular risk factors; including hypertension, diabetes, dyslipidemia, and obesity. To study the effects of estrogen depletion on skeletal muscle metabolic activity, seventeen female C57BL/6 mice have been randomly divided into two groups for the duration of 60 days; ovariectomized (OVX) and control. Circulating concentrations of total cholesterol, high–density lipoprotein, and glucose were measured prior to surgery and at 20, 40, and 60 days post-surgery. Pre- and post-trial measurements of body composition were measured on the EchoMRI. Body weight was measured weekly and food intake was calculated during a one week period. Twenty-four hour cage activity was monitored in activity chambers at 50 days. Enzymatic activity of skeletal muscle will be measured to assess oxidative capacity and rates of fatty-acid breakdown. Early results indicate that the OVX mice are gaining weight and have increased total cholesterol over baseline values. I hypothesize that estrogen-depletion will increase circulating cholesterol and glucose levels, decrease circulating high-density lipid, increase body mass and percent body fat, decrease cage activities, and decrease skeletal muscle oxidative capacity and lipid metabolism through reduced enzymatic activity.Item Interview with Frederic Kottke(University of Minnesota, 2010-02-04) Tobbell, Dominique A.; Kottke, FredericFrederic Kottke begins by describing some of his background, including his education and why he went into medicine and specifically physical medicine and rehabilitation. He briefly talks about the establishment of the Department of Physical Medicine and Rehabilitation; the integrative and interdisciplinary approach to medicine in physical medicine and rehabilitation; the different types of patients he saw; funding at the University of Minnesota; perceptions in the 1960s that there was a shortage of physicians; the Medical School curriculum revisions in the 1960s; the faculty practice issue; the attempt to establish a medical school in St. Paul; the reorganization of the health sciences in 1970; Lyle French and Neal Gault; the establishment of the Program in Human Sexuality; the support of members of Congress; and the VA Hospital.Item Interview with Thomas Kottke(University of Minnesota, 2010-03-25) Tobbell, Dominique A.; Kottke, ThomasThomas Kottke begins by discussing his background, including his education and why he became a physician. He discusses his time as a medical student at the University of Minnesota; going to McGill University for his residency; some of his experiences as a faculty member at the University of Minnesota Medical School, and getting the Preventive Cardiology Academic Award and his work on tobacco control and smoking. He described his impressions of the new Medical School curriculum as a student, his experience at a Sexual Attitude Reassessment Seminar, his experiences on the Council of Deans and Directors as a student representative, the perceived shortage of doctors in the 1960s, the relationship between the Medical School and the Mayo Clinic, and the reorganization of the health sciences in 1970. He discusses the Council for Health Interdisciplinary Participation (CHIP), family medicine, the recruitment of minority students, women students, and the affiliated hospitals. He discusses his father, Frederick Kottke, and his father’s connections with Democratic Congressional members, including Hubert Humphrey.