Browsing by Author "Romsa, Amanda Marie"

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    Histone deacetylase 3 and histone deacetylase 7 Have opposite effects on osteoclast differentiation.
    (2010-06) Romsa, Amanda Marie
    Histone deacetylases (HDACs) are negative regulators of transcription. Endochondral bone formation including chrondocyte and osteoblast maturation is regulated by HDACs. Very little is known about the role HDACs play in osteoclast differentiation. This study found that suppression of HDAC3 expression represses osteoclastogenesis, while osteoclasts suppressed for HDAC7 expression had accelerated differentiation compared to control cells.