Histone deacetylase 3 and histone deacetylase 7 Have opposite effects on osteoclast differentiation.

Romsa, Amanda Marie
2010-06
Thumbnail Image

View/Download File

Romsa_Amanda_June2010.pdf (467.38 KB)

Persistent link to this item

https://hdl.handle.net/11299/93344
Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

Histone deacetylase 3 and histone deacetylase 7 Have opposite effects on osteoclast differentiation.

Authors

Published Date

2010-06

Publisher

Type

Thesis or Dissertation

Abstract

Histone deacetylases (HDACs) are negative regulators of transcription. Endochondral bone formation including chrondocyte and osteoblast maturation is regulated by HDACs. Very little is known about the role HDACs play in osteoclast differentiation. This study found that suppression of HDAC3 expression represses osteoclastogenesis, while osteoclasts suppressed for HDAC7 expression had accelerated differentiation compared to control cells.

Keywords

Description

University of Minnesota M.S. thesis. June 2010. Major: Dentistry. Advisor: Dr. Kim Mansky. 1 computer file (PDF); vi, 21 pages, appendices I-III. Ill. (some col.)

Related to

Replaces

License

Collections

Master's Theses (Plan A and Professional Engineering Design Projects)

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Romsa, Amanda Marie. (2010). Histone deacetylase 3 and histone deacetylase 7 Have opposite effects on osteoclast differentiation.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/93344.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.