Browsing by Author "Roensch, Kristin"
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Item MiRNA-155 Regulates IL-12 Expression by Targeting SOCS-1 in Human Dendritic Cells(2010-04-21) Roensch, KristinDendritic cells (DCs) are the most potent type of white blood cells that regulate the immune response. DCs’ antigen processing activities are controlled in response to inflammatory stimuli. DCs play a unique role in the immune activation to pathogens and transformed cells. MicroRNAs (miRNAs) are small, single-stranded non-coding RNAs that function through stem-loop binding to the 3’ untranslated regions (UTRS) of target mRNAs, usually silencing its protein’s production and degrading the mRNA itself. Aims of the study: 1. Understand miR-155’s role during monocyte-derived dendritic cell maturation. 2. Understand mechanism by which miR-155 functions during dendritic cell development.