MiRNA-155 Regulates IL-12 Expression by Targeting SOCS-1 in Human Dendritic Cells

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MiRNA-155 Regulates IL-12 Expression by Targeting SOCS-1 in Human Dendritic Cells

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Roensch, Kristin

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2010-04-21

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Abstract

Dendritic cells (DCs) are the most potent type of white blood cells that regulate the immune response. DCs’ antigen processing activities are controlled in response to inflammatory stimuli. DCs play a unique role in the immune activation to pathogens and transformed cells. MicroRNAs (miRNAs) are small, single-stranded non-coding RNAs that function through stem-loop binding to the 3’ untranslated regions (UTRS) of target mRNAs, usually silencing its protein’s production and degrading the mRNA itself. Aims of the study: 1. Understand miR-155’s role during monocyte-derived dendritic cell maturation. 2. Understand mechanism by which miR-155 functions during dendritic cell development.

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College of Biological Sciences

Academic Health Center

Division of Pediatric Blood and Marrow Transplantation

Masonic Cancer Center

Center for Immunology

Center for Genome Engineering

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Additional contributors: Changming Lu; Xin Huang; Xianzheng Zhou (faculty mentor)

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UMTC Undergraduate Research Presentations and Papers (UROP)

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This work was supported by University of Minnesota Masonic Cancer Center and Department of Pediatrics startup funds, the Children’s Cancer Research Fund in Minneapolis, the Sidney Kimmel Foundation for Cancer Research Kimmel Scholar Program, and University of Minnesota Academic Health Center Translational Research Grant.

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Roensch, Kristin. (2010). MiRNA-155 Regulates IL-12 Expression by Targeting SOCS-1 in Human Dendritic Cells. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/90478.

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