Browsing by Author "McCue, Molly E"

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    Cardea SOLO and Televet measurements on 12 horses
    (2024-04-25) Durward-Akhurst, Sian A; Hauser, Robert G; Dias, Tatiana D; McCue, Molly E; durwa004@umn.edu; Durward-Akhurst, Sian A; University of Minnesota Department of Veterinary Clinical Sciences
    The Cardea SOLOTM (CS) is a single-use monitor with automated ECG analysis software allowing for ECG monitoring for approximately 7 days. ECGs were performed on 12 healthy horses simultaneously using both devices for 24 hours on day 1 and day 7, with the CS left in place for all seven days. Bland-Altman analysis and intraclass correlation were performed to test for agreement between the two devices for standard ECG measurements performed on both ECG traces.
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    VCF of insertions and deletions found at high levels in multi breed Equus caballus population
    (2025-04-28) Marlowe, Jillian L; Durward-Akhurst, Sian A; McCue, Molly E; marlo072@umn.edu; Marlowe, Jillian; University of Minnesota Equine Genetics and Genomics Lab
    Datasets containing high confidence single nucleotide polymorphisms that exist in the genome of horses have previously been published in support of population genetic studies, disease variant discovery, and other type of genetic research. There are no similar datasets for insertions and deletions (indels). Here we created a preliminary set of indels that exist within a certain range of allele frequencies in a large diverse population of apparently healthy horses. A total of ~2M indels passed GATK filtering thresholds and had an allele frequency between 1% and 60%. Though the criteria for inclusion in this dataset are lenient to increase the total numbers these loci are likely to exist in the equine genome and can be used as a preliminary set of indels for some genetic studies. So far this set of indels has been used to create simulated equine genomes that will be used as a benchmarking measure of variant calling and genotyping methods.