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Browsing by Author "Huchthausen, Margaretta"

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    The Role of Macrophages in Developmental Programming of Type 2 Diabetes
    (2021-03-15) Molin, Alexa M; Root, Kate; Polack, Vonda; Huchthausen, Margaretta; Regal, Jean
    Hypertensive disorders are a common pregnancy complication that can increase the risk of developing type 2 diabetes (T2D) in offspring. Preeclampsia, a hypertensive disorder characterized by high blood pressure with new-onset proteinuria is initiated by placental ischemia. Studies from the Regal lab showed placental ischemia induced hypertension in female rat offspring leads to a reduced β-cell area associated with an increase in pancreatic islet macrophages. Therefore, depletion of macrophages may allow beta-cell area to recover and lower the risk of T2D. The goal of this study is to deplete macrophages in the pancreatic islets using Clophosome clodronate injections of postnatal day 13 female rats.