The Role of Macrophages in Developmental Programming of Type 2 Diabetes
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The Role of Macrophages in Developmental Programming of Type 2 Diabetes
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2021-03-15
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Hypertensive disorders are a common pregnancy complication that can increase the risk of developing type 2 diabetes (T2D) in offspring. Preeclampsia, a hypertensive disorder characterized by high blood pressure with new-onset proteinuria is initiated by placental ischemia. Studies from the Regal lab showed placental ischemia induced hypertension in female rat offspring leads to a reduced β-cell area associated with an increase in pancreatic islet macrophages. Therefore, depletion of macrophages may allow beta-cell area to recover and lower the risk of T2D. The goal of this study is to deplete macrophages in the pancreatic islets using Clophosome clodronate injections of postnatal day 13 female rats.
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Biochemistry, Biology, Chemistry. University of Minnesota Duluth; Department of Biomedical Sciences
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University of Minnesota's Undergraduate Research Opportunities Program
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Molin, Alexa M; Root, Kate; Polack, Vonda; Huchthausen, Margaretta; Regal, Jean. (2021). The Role of Macrophages in Developmental Programming of Type 2 Diabetes. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/219067.
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