Between Dec 19, 2024 and Jan 2, 2025, datasets can be submitted to DRUM but will not be processed until after the break. Staff will not be available to answer email during this period, and will not be able to provide DOIs until after Jan 2. If you are in need of a DOI during this period, consider Dryad or OpenICPSR. Submission responses to the UDC may also be delayed during this time.
 

The Role of Macrophages in Developmental Programming of Type 2 Diabetes

Molin, Alexa M
Root, Kate
Polack, Vonda
Huchthausen, Margaretta
Regal, Jean
2021-03-15
Thumbnail Image

View/Download File

Role of Macrophages in Developmental Programming of Type 2 Diabetes (564.01 KB)

Persistent link to this item

https://hdl.handle.net/11299/219067
Statistics
View Statistics

Journal Title

Journal ISSN

Volume Title

Title

The Role of Macrophages in Developmental Programming of Type 2 Diabetes

Authors

Published Date

2021-03-15

Publisher

Type

Presentation

Abstract

Hypertensive disorders are a common pregnancy complication that can increase the risk of developing type 2 diabetes (T2D) in offspring. Preeclampsia, a hypertensive disorder characterized by high blood pressure with new-onset proteinuria is initiated by placental ischemia. Studies from the Regal lab showed placental ischemia induced hypertension in female rat offspring leads to a reduced β-cell area associated with an increase in pancreatic islet macrophages. Therefore, depletion of macrophages may allow beta-cell area to recover and lower the risk of T2D. The goal of this study is to deplete macrophages in the pancreatic islets using Clophosome clodronate injections of postnatal day 13 female rats.

Keywords

Description

Biochemistry, Biology, Chemistry. University of Minnesota Duluth; Department of Biomedical Sciences

Related to

Replaces

License

Collections

UMD Undergraduate Research Opportunities Program Student Works

Series/Report Number

Funding information

University of Minnesota's Undergraduate Research Opportunities Program

Isbn identifier

Doi identifier

Previously Published Citation

Other identifiers

Suggested citation

Molin, Alexa M; Root, Kate; Polack, Vonda; Huchthausen, Margaretta; Regal, Jean. (2021). The Role of Macrophages in Developmental Programming of Type 2 Diabetes. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/219067.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.