Regulators of Complement System Activation Change with Placental Ischemiainduced Hypertension in Rat

Abstract

Preeclampsia is characterized by new onset hypertension, reduced placental perfusion, and increased activation of the complement system, part of the innate immune system. It remains the leading cause of mortality and morbidity in mother and fetus, complicating 28% of pregnancies (Steegers et al, 2010). This condition results in decreased blood flow to the placenta due to abnormal remodeling of uterine arteries. This can lead to lower birth weight and preterm birth. Besides administering medication to reduce blood pressure with possible adverse effects on the fetus, there is no therapy except delivery of the placenta (Steegers et al, 2010).