In Search of The Psychosis Continuum In The Human Connectome
2020-09
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
In Search of The Psychosis Continuum In The Human Connectome
Authors
Published Date
2020-09
Publisher
Type
Thesis or Dissertation
Abstract
Psychosis is known to exist on a continuum in the population, ranging from infrequent, subclinical psychotic-like experiences to full-blown psychotic disorders. Resting-state functional connectivity studies report widespread dysconnectivity at various points along the psychosis continuum, yet a comprehensive mapping of psychosis in the human connectome remains elusive. This dissertation aims to build a resting-state functional connectivity model reproducible and generalizable across the psychosis continuum with a systematic approach to large community and clinical samples. Measurement properties of the human connectome derived with various methods were first compared to identify the human connectome with optimal test-retest reliability. The identified human connectome was then used to build a cross-validated model for psychotic-like experiences in a large community sample (N = 855). Lastly, this model was validated in a clinical sample with patients with psychosis and first-degree relatives. Findings suggest that independent component analysis with dimensionalities above 100 yielded human connectomics with optimal reliability. A model involving primarily connections in the frontoparietal, default, cingulo-opercular, and dorsal attention networks explained as much as 3.4% of variance in psychotic-like experiences in healthy adults. In the clinical sample, model score explained psychoticism and schizotypy across patients with psychosis, first-degree relatives, and healthy controls (partial correlation ranged from 0.19 to 0.51). Findings provide direct evidence for the psychosis continuum encoded in the human connectome. The quantifiable resting state functional connectivity model facilitates validation in additional samples and shows preliminary potential for clinical utility.
Description
University of Minnesota Ph.D. dissertation. 2020. Major: Psychology. Advisor: Angus MacDonald. 1 computer file (PDF); 148 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Ma, Yizhou. (2020). In Search of The Psychosis Continuum In The Human Connectome. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/217784.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.