BEHAVIORAL PREDICTORS OF INDIVIDUAL DIFFERENCES IN OPIOID ADDICTION VULNERABILITY
2021-04
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
BEHAVIORAL PREDICTORS OF INDIVIDUAL DIFFERENCES IN OPIOID ADDICTION VULNERABILITY
Authors
Published Date
2021-04
Publisher
Type
Thesis or Dissertation
Abstract
Understanding behavioral predictors of individual differences in opioid addiction vulnerability could provide critical insights into the mechanisms underlying opioid addiction and could lead to more effective treatments. However, very few behavioral predictors of individual differences in opioid self-administration (SA), a key preclinical model of opioid addiction, have been established. The goal of this dissertation was to evaluate several potential behavioral predictors of individual differences in morphine SA in rats, and to establish novel methodologies for studying opioid addiction vulnerability using the SA paradigm. Study 1 showed that spontaneous locomotor activity in a novel environment, an animal model of sensation-seeking that predicts SA of several drugs of abuse (e.g., stimulants), did not predict individual differences in morphine SA. Study 2 found that greater severity of anhedonia-like behavior during withdrawal from acute morphine exposure (withdrawal-induced anhedonia, WIA) predicted subsequent lower acquisition, demand, and reinstatement of morphine SA. Study 3 showed the feasibility of using regularized factor analysis on morphine SA measures, and revealed that a common latent factor underlies four separate measures of morphine SA. Additionally, while acquisition, demand and morphine-induced reinstatement associated closely with the common latent Addiction factor, stress-induced reinstatement did not. Overall, these studies extended the opioid individual differences literature by establishing WIA as one of the first behavioral predictors of opioid SA, and also expanded the range of analytical tools to be utilized in preclinical behavioral studies.
Description
University of Minnesota Ph.D. dissertation. April 2021. Major: Psychology. Advisors: Andrew Harris, Jonathan Gewirtz. 1 computer file (PDF); vii, 126 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Swain, Yayi. (2021). BEHAVIORAL PREDICTORS OF INDIVIDUAL DIFFERENCES IN OPIOID ADDICTION VULNERABILITY. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/223118.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.