Multiscale and Multiphysics of Blood Flow and Arterial Mechanics Growth and Remodeling
2024-01
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Multiscale and Multiphysics of Blood Flow and Arterial Mechanics Growth and Remodeling
Authors
Published Date
2024-01
Publisher
Type
Thesis or Dissertation
Abstract
The circulatory system, resembling a complex network of pipes (blood vessels) and a ceaseless pumping system (heart), orchestrates the delivery of oxygen and nutrients to every cell and tissue in the human body. Unlike conventional engineering pipes, vascular tissue exhibits the remarkable ability to adapt its physical and mechanical properties in response to its environment, a phenomenon known as growth and remodeling (G&R). This process aims to maintain a balanced stress level, termed homeostatic stress.In healthy arteries, maintaining mechanical equilibrium involves a clever negative feedback loop that restores the system to its preferred state after any disturbances. However, when this delicate balance is disrupted, it can lead to a phenomenon called pathological G&R, characterized by a positive feedback loop. Aortic and intracranial aneurysms are prominent examples of this disrupted G&R. Characterized by the enlargement of vessels, aneurysms pose significant health risks, contributing to numerous annual fatalities. Moreover, blood disorders such as sickle cell disease can disrupt mechanical equilibrium by altering blood flow dynamics and creating localized hypoxia, especially in small arteries, such as the one found in our brain. Therefore, recognizing the connection between blood disorders and tissue-related diseases underscores the importance of exploring the interplay between fluid dynamics and tissue mechanics. This thesis investigates the interplay between computational fluid dynamics, mathematical modeling, and finite element analysis in the context of cardiovascular diseases. It primarily focuses on ascending thoracic and intracranial aneurysms related to sickle cell disease. We aim to enhance our understanding of the intricate mechanisms underlying vascular diseases. This heightened insight will be central in developing more holistic diagnostic and therapeutic approaches to effectively lessen their significant impact on individuals' health.
Description
University of Minnesota Ph.D. dissertation. January 2024. Major: Material Science and Engineering. Advisor: Victor Barocas. 1 computer file (PDF); xxiii, 232 pages.
Related to
Replaces
License
Collections
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Suggested citation
Schmidt Bazzi, Marisa. (2024). Multiscale and Multiphysics of Blood Flow and Arterial Mechanics Growth and Remodeling. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/262883.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.