Mathematical Modeling of Cell Migration: Mechanisms in Dictyostelium discoideum.

Abstract

This study aims to understand the biochemical pathways involved in the cytoskeleton of Dictyostelium discoideum, particularly the self-organization process of actin structures. While previous models have explored protein dynamics in various contexts, they tend to oversimplify the underlying biochemical mechanisms. This study presents two extended models that offer updated insights into the chemical interactions and feedback mechanisms of Dictyostelium discoideum. The first model explores how bistability emerges from the topology of the underlying network, while the second model focuses on the mechanisms of filopodia initiation and the role of membrane curvature in their emergence.