Morphology and Three-Dimensional Inhalation Flow in Human Airways in Healthy and Diseased Subjects
2017-09
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Morphology and Three-Dimensional Inhalation Flow in Human Airways in Healthy and Diseased Subjects
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2017-09
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We investigate experimentally the relation between anatomical structure and respiratory function in healthy and diseased airways. Computed Tomography (CT) scans of human lungs are analyzed from the data base of a large multi-institution clinical study on Chronic Obstructive Pulmonary Disease (COPD). Through segmentation, the 3D volumes of the airways are determined at total lung capacity. A geometric analysis provides data on the morphometry of the airways, including the length and diameter of branches, the child-to-parent diameter ratio, and branching angles. While several geometric parameters are confirmed to match past studies for healthy subjects, previously unreported trends are reported on the length of branches. Specifically, in most dichotomous airway bifurcation, the branch of smaller diameter tends to be significantly longer than the one of larger diameter. Additionally, the branch diameter tends to be smaller in diseased airways than in healthy airways up to the 7th generation of bronchial branching. 3D fractal analysis is also performed on the airway volume. Fractal dimensions of 1.89 and 1.83 are found for healthy non-smokers and declining COPD subjects, respectively, furthering the belief that COPD (and lung disease in general) significantly affects the morphometry of the airways already in early stages of the disease. To investigate the inspiratory flow, 3D flow models of the airways are generated using Computer Aided Design (CAD) software and 3D printed. Using Magnetic Resonance Velocimetry (MRV), 3-component 3D flow fields are acquired for steady inhalation at Reynolds number Re ~ 2000 defined at the trachea. Analysis of the flow data reveals that diseased subjects may experience greater secondary flow strength in their conducting airways, especially in deeper generations.
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University of Minnesota M.S. thesis.September 2017. Major: Aerospace Engineering and Mechanics. Advisor: Filippo Coletti. 1 computer file (PDF); vi, 53 pages.
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Van de Moortele, Tristan. (2017). Morphology and Three-Dimensional Inhalation Flow in Human Airways in Healthy and Diseased Subjects. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/191201.
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