Synthesis of diaryliodonium salts for use in nucleophilic substitution reactions
2014-08
Loading...
View/Download File
Persistent link to this item
Statistics
View StatisticsJournal Title
Journal ISSN
Volume Title
Title
Synthesis of diaryliodonium salts for use in nucleophilic substitution reactions
Alternative title
Authors
Published Date
2014-08
Publisher
Type
Thesis or Dissertation
Abstract
Diaryliodonium salts are a type of hypervalent iodine compound that are capable of arylating a variety of nucleophiles. Unsymmetrical diaryliodonium salts provide varying degrees of selectivity during reactions with nucleophiles where one aryl group is preferentially transferred to the nucleophile. It is the goal of this research to develop a diaryliodonium salt where the substituents on one of the aryl groups are modified in such a manner that it causes a nucleophile to couple with the other aryl group with >95% selectivity. This research finds practical application as it relates to Positron Emission Tomography (PET). Positron Emission Tompgraphy is an area of molecular imaging that is used to visualize human physiology by the detection of positron-emitting radiopharmaceuticals labeled with short lived positron-emitting radionuclides. Recent research has focused on efficiently introducing the [18F]fluoride ion into an aryl group of diaryliodonium salts.
Keywords
Description
University of Minnesota Master of Science thesis. August 2014. Major: Chemistry. Advisors: Viktor V. Zhdankin and Akira Yoshimura. 1 computer file (PDF); viii, 53 pages, appendix p. 44-53.
Related to
Replaces
License
Series/Report Number
Funding information
Isbn identifier
Doi identifier
Previously Published Citation
Other identifiers
Suggested citation
Kastern, Brent Jerrad. (2014). Synthesis of diaryliodonium salts for use in nucleophilic substitution reactions. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/166804.
Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.