Evaluation of the Role of Cytomegalovirus Infection in the Development of Acute Lymphoblastic Leukemia and Other Cancers

Loading...

View/Download File

Geris_umn_0130E_23381.pdf (1.59 MB)

Persistent link to this item

https://hdl.handle.net/11299/241588

Statistics

View Statistics

Journal Title

Journal ISSN

Volume Title

Title

Evaluation of the Role of Cytomegalovirus Infection in the Development of Acute Lymphoblastic Leukemia and Other Cancers

Authors

Geris, Jennifer

Published Date

2022-05

Publisher

Type

Thesis or Dissertation

Abstract

Acute lymphoblastic leukemia (ALL) is the most prevalent pediatric malignancy, and a leading cause of death in children. Understanding the risk factors of pediatric ALL is necessary to enable early detection and prevention. Congenital cytomegalovirus (cCMV) has recently been identified as a possible risk factor of ALL. In Manuscript 1, we compared the prevalence of cCMV infection in newborn dried blood spots of ALL cases and cancer-free controls. There was no difference in the odds of cCMV infection comparing ALL cases to controls in our primary analysis. However, cCMV was significantly more prevalent among hyperdiploid ALL cases compared to unmatched controls. These findings offer partial support for the association of cCMV with ALL.CMV is among the most common viral infections following solid organ transplantation (SOT). CMV disease post-SOT has been associated with an increased risk of subsequent non-Hodgkin lymphoma but has not been well-studied for other hematologic malignancies. In Manuscript 2, we aimed to describe CMV infection status pre-transplant as it relates to the incidence of leukemias, lymphomas, and myeloma. We identified that CMV recipient and donor sero-mismatch (R-/D+) was associated with significantly lower risk of diffuse large B-cell lymphoma compared to CMV seronegative R/D pairs, indicating CMV may have a protective role in carcinogenesis. Lastly, in Manuscript 3, we leveraged the same dataset as Manuscript 2 to examine associations of CMV with solid tumor cancer risk among SOT recipients. Using linked data from the United States SOT registry and 32 cancer registries, we report an inverse association between R-/D+ CMV serostatus and small intestine cancer, and a positive association between CMV R+ serostatus and lung cancer. CMV status was not associated with risk for other cancers. Findings from this dissertation may motivate and inform future work to further understand the relationship between this highly prevalent virus and cancer.

Keywords

ALL

Cytomegalovirus

Leukemia

Solid organ transplantation

Description

University of Minnesota Ph.D. dissertation. 2022. Major: Epidemiology. Advisor: Logan Spector. 1 computer file (PDF); 132 pages.

Related to

Replaces

License

Collections

Dissertations

Series/Report Number

Funding information

Isbn identifier

Doi identifier

Previously Published Citation

Suggested citation

Geris, Jennifer. (2022). Evaluation of the Role of Cytomegalovirus Infection in the Development of Acute Lymphoblastic Leukemia and Other Cancers. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/241588.

Content distributed via the University Digital Conservancy may be subject to additional license and use restrictions applied by the depositor. By using these files, users agree to the Terms of Use. Materials in the UDC may contain content that is disturbing and/or harmful. For more information, please see our statement on harmful content in digital repositories.