Mechanical Stimulation of Fibroblasts using Low-Cost In Vitro Ultrasound System (LIVUS)
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Mechanical stimulation of cells using low intensity ultrasound waves has proven effective for increasing proliferation and contractility of fibroblasts. Such changes in cell behavior could be key to improving wound or graft healing after medical intervention by way of improving ECM foundation within the wound site. Previous work conducted within the lab confirmed genetic changes and cell remodeling caused by mechanical stimulation, providing a basis for observing the mechanical changes a cell undergoes during such stimulation. Our results indicate that cells become more contractile and actin remodeling occurs within fibroblasts when stimulated using low intensity ultrasound. Results also indicate that these changes can be reversed by way of treating fibroblasts with Rho-Kinase Inhibitor Y-27632 prior to mechanical stimulation.
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University of Minnesota M.S. thesis. 2026. Major: Biomedical Engineering. Advisor: Patrick Alford. 1 computer file (PDF); v, 30 pages.
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Heil, Matthew. (2026). Mechanical Stimulation of Fibroblasts using Low-Cost In Vitro Ultrasound System (LIVUS). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/280263.
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